PMID- 28285191
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20181113
IS  - 2213-2317 (Electronic)
IS  - 2213-2317 (Linking)
VI  - 12
DP  - 2017 Aug
TI  - Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of 
      ROS/NF-kappaB signaling via downregulation of HNF1b.
PG  - 300-310
LID - S2213-2317(17)30098-8 [pii]
LID - 10.1016/j.redox.2017.02.026 [doi]
AB  - Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants 
      (POPs) that act as endocrine-disrupting chemicals. In the current study, we 
      examined the mechanism underlying the effect of PCB-153 on glucose and lipid 
      metabolism in vivo and in vitro. We found that PCB-153 induced per se and 
      worsened high fat diet (HFD)-resulted increase of blood glucose level and glucose 
      and insulin intolerance. In addition, PCB-153 induced per se and worsened 
      HFD-resulted increase of triglyceride content and adipose mass. Moreover, PCB-153 
      concentration-dependently inhibited insulin-dependent glucose uptake and lipid 
      accumulation in cultured hepatocytes and adipocytes. PCB-153 induced the 
      expression and nuclear translocation of p65 NF-kappaB and the expression of its 
      downstream inflammatory markers, and worsened HFD-resulted increase of those 
      inflammatory markers. Inhibition of NF-kappaB significantly suppressed 
      PCB-153-induced inflammation, lipid accumulation and decrease of glucose uptake. 
      PCB-153 induced oxidative stress and decreased hepatocyte nuclear factor 1b 
      (HNF1b) and glutathione peroxidase 1 (GPx1) expression in vivo and in vitro. 
      Overexpression of HNF1b increased GPx1 expression, decreased ROS level, decreased 
      Srebp1, ACC and FAS expression, and inhibited PCB-153-resulted oxidative stress, 
      NF-kappaB-mediated inflammation, and final glucose/lipid metabolic disorder. Our 
      results suggest that dysregulation of HNF1b/ROS/NF-kappaB plays an important role in 
      PCB-153-induced glucose/lipid metabolic disorder.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Wu, Hao
AU  - Wu H
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Yu, Weihua
AU  - Yu W
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Meng, Fansen
AU  - Meng F
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Mi, Jie
AU  - Mi J
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Peng, Jie
AU  - Peng J
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Liu, Jiangzheng
AU  - Liu J
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Zhang, Xiaodi
AU  - Zhang X
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Hai, Chunxu
AU  - Hai C
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, 
      the Ministry of Education Key Lab of Hazard Assessment and Control in Special 
      Operational Environment, School of Public Health, Fourth Military Medical 
      University, Xi'an 710032, China. Electronic address: xinwang@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170307
PL  - Netherlands
TA  - Redox Biol
JT  - Redox biology
JID - 101605639
RN  - 0 (Hnf1b protein, mouse)
RN  - 0 (NF-kappa B)
RN  - 0 (Reactive Oxygen Species)
RN  - 138674-15-4 (Hepatocyte Nuclear Factor 1-beta)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipose Tissue/drug effects/metabolism
MH  - Animals
MH  - Cell Line
MH  - Diet, High-Fat/adverse effects
MH  - *Down-Regulation
MH  - Glucose Intolerance/chemically induced
MH  - Hepatocyte Nuclear Factor 1-beta/*metabolism
MH  - Hepatocytes/drug effects/metabolism
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Metabolic Syndrome/*chemically induced/metabolism
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - Polychlorinated Biphenyls/*adverse effects/pharmacology
MH  - Reactive Oxygen Species/metabolism
MH  - *Signal Transduction
PMC - PMC5345977
OTO - NOTNLM
OT  - Glucose and lipid metabolic disorder
OT  - Hepatocyte nuclear factor 1b
OT  - NF-kappaB
OT  - Polychlorinated biphenyls
OT  - Reactive oxygen species
EDAT- 2017/03/13 06:00
MHDA- 2018/03/21 06:00
PMCR- 2017/03/07
CRDT- 2017/03/13 06:00
PHST- 2017/02/07 00:00 [received]
PHST- 2017/02/25 00:00 [revised]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/03/13 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
PHST- 2017/03/13 06:00 [entrez]
PHST- 2017/03/07 00:00 [pmc-release]
AID - S2213-2317(17)30098-8 [pii]
AID - 10.1016/j.redox.2017.02.026 [doi]
PST - ppublish
SO  - Redox Biol. 2017 Aug;12:300-310. doi: 10.1016/j.redox.2017.02.026. Epub 2017 Mar 
      7.