PMID- 28285207
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20181202
IS  - 1872-7506 (Electronic)
IS  - 0925-4927 (Linking)
VI  - 263
DP  - 2017 May 30
TI  - Self-referential processing in unipolar depression: Distinct roles of subregions 
      of the medial prefrontal cortex.
PG  - 8-14
LID - S0925-4927(16)30076-2 [pii]
LID - 10.1016/j.pscychresns.2017.02.008 [doi]
AB  - Self-concept is used to explain emotional disturbance or other behavioural and 
      psychological problems associated with depression. Self-referential processing 
      generally reflects self-concept in different domains. Cortical midline 
      structures, such as the medial prefrontal cortex (MPFC), are critical for 
      self-referential processing both in healthy controls and depressive patients. 
      However, the role of subregions of the MPFC in self-referential processing in 
      depression remains uncertain. In this study, we aimed to explore the neural basis 
      of self-referential processing in depressive patients and the 
      activation-deactivation patterns of subregions of the MPFC. Nineteen depressive 
      patients and 21 controls completed the classic self-referential task with two 
      different judgement conditions: self-referential processing and semantic 
      processing. In the self-referential condition, with analysis of the two sample 
      t-test unipolar patients showed significantly higher activation of the central 
      MPFC and significantly lower activation of the dorsal MPFC, relative to controls. 
      The results substantially suggested that the different activation of the MPFC may 
      be selectively involved in self-referential processing in depressive patients, 
      potentially indicating abnormal engagement of cognitive control and emotion 
      regulation in this group.
CI  - Copyright (c) 2017 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Yu
AU  - Li Y
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Li, Mengze
AU  - Li M
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Wei, Dongtao
AU  - Wei D
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Kong, Xia
AU  - Kong X
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Du, Xue
AU  - Du X
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Hou, Xin
AU  - Hou X
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Sun, Jiangzhou
AU  - Sun J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Qiu, Jiang
AU  - Qiu J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China. Electronic address: qiuj318@swu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170303
PL  - Netherlands
TA  - Psychiatry Res Neuroimaging
JT  - Psychiatry research. Neuroimaging
JID - 101723001
SB  - IM
MH  - Adult
MH  - Depressive Disorder/*diagnostic imaging/psychology
MH  - Emotions/physiology
MH  - Female
MH  - Humans
MH  - Judgment/physiology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Photic Stimulation/methods
MH  - Prefrontal Cortex/*diagnostic imaging/*physiology
MH  - Psychomotor Performance/*physiology
MH  - *Self Concept
MH  - Young Adult
OTO - NOTNLM
OT  - MPFC
OT  - Self-reference
OT  - Task fMRI
OT  - Unipolar depression
EDAT- 2017/03/13 06:00
MHDA- 2017/12/14 06:00
CRDT- 2017/03/13 06:00
PHST- 2016/03/26 00:00 [received]
PHST- 2016/11/28 00:00 [revised]
PHST- 2017/02/23 00:00 [accepted]
PHST- 2017/03/13 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
PHST- 2017/03/13 06:00 [entrez]
AID - S0925-4927(16)30076-2 [pii]
AID - 10.1016/j.pscychresns.2017.02.008 [doi]
PST - ppublish
SO  - Psychiatry Res Neuroimaging. 2017 May 30;263:8-14. doi: 
      10.1016/j.pscychresns.2017.02.008. Epub 2017 Mar 3.