PMID- 28285594
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Mar 13
TI  - Defining left ventricular remodeling following acute ST-segment elevation 
      myocardial infarction using cardiovascular magnetic resonance.
PG  - 26
LID - 10.1186/s12968-017-0343-9 [doi]
LID - 26
AB  - BACKGROUND: The assessment of post-myocardial infarction (MI) left ventricular 
      (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses 
      criteria defined by echocardiography. Our aim was to provide CMR criteria for 
      assessing LV remodeling following acute MI. METHODS: Firstly, 40 reperfused 
      ST-segment elevation myocardial infarction (STEMI) patients with paired acute 
      (4 +/- 2 days) and follow-up (5 +/- 2 months) CMR scans were analyzed by 2 
      independent reviewers and the minimal detectable changes (MDCs) for percentage 
      change in LV end-diastolic volume (%DeltaLVEDV), LV end-systolic volume (%DeltaLVESV), 
      and LV ejection fraction (%DeltaLVEF) between the acute and follow-up scans were 
      determined. Secondly, in 146 reperfused STEMI patients, receiver operator 
      characteristic curve analyses for predicting LVEF <50% at follow-up (as a 
      surrogate for clinical poor clinical outcome) were undertaken to obtain cut-off 
      values for %DeltaLVEDV and %DeltaLVESV. RESULTS: The MDCs for %DeltaLVEDV, %DeltaLVESV, and 
      %DeltaLVEF were similar at 12%, 12%, 13%, respectively. The cut-off values for 
      predicting LVEF < 50% at follow-up were 11% for %DeltaLVEDV on receiver operating 
      characteristic curve analysis (area under the curve (AUC) 0.75, 95% CI 0.6 to 
      0.83, sensitivity 72% specificity 70%), and 5% for %DeltaLVESV (AUC 0.83, 95% CI 0.77 
      to 0.90, sensitivity and specificity 78%). Using cut-off MDC values (higher than 
      the clinically important cut-off values) of 12% for both %DeltaLVEDV and %DeltaLVESV, 4 
      main patterns of LV remodeling were identified in our cohort: reverse LV 
      remodeling (LVEF predominantly improved); no LV remodeling (LVEF predominantly 
      unchanged); adverse LV remodeling with compensation (LVEF predominantly 
      improved); and adverse LV remodeling (LVEF unchanged or worsened). CONCLUSIONS: 
      The MDCs for %DeltaLVEDV and %DeltaLVESV between the acute and follow-up CMR scans of 12% 
      each may be used to define adverse or reverse LV remodeling post-STEMI. The MDC 
      for %DeltaLVEF of 13%, relative to baseline, provides the minimal effect size 
      required for investigating treatments aimed at improving LVEF following acute 
      STEMI.
FAU - Bulluck, Heerajnarain
AU  - Bulluck H
AUID- ORCID: 0000-0002-1985-1783
AD  - The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, 
      University College London, London, UK. h.bulluck@gmail.com.
AD  - The National Institute of Health Research, University College London Hospitals, 
      Biomedical Research Centre, London, UK. h.bulluck@gmail.com.
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 
      Singapore, Singapore. h.bulluck@gmail.com.
FAU - Go, Yun Yun
AU  - Go YY
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 
      Singapore, Singapore.
FAU - Crimi, Gabriele
AU  - Crimi G
AD  - Struttura Complessa Cardiologia, Fondazione Istituto Di Ricovero e Cura a 
      Carattere Scientifico (IRCCS), Policlinico San Matteo, Pavia, Italy.
FAU - Ludman, Andrew J
AU  - Ludman AJ
AD  - Royal Devon and Exeter Hospital, NHS Foundation Trust, Exeter, UK.
FAU - Rosmini, Stefania
AU  - Rosmini S
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Abdel-Gadir, Amna
AU  - Abdel-Gadir A
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Bhuva, Anish N
AU  - Bhuva AN
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Treibel, Thomas A
AU  - Treibel TA
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Fontana, Marianna
AU  - Fontana M
AD  - Royal Free Hospital, London, UK.
FAU - Pica, Silvia
AU  - Pica S
AD  - Struttura Complessa Cardiologia, Fondazione Istituto Di Ricovero e Cura a 
      Carattere Scientifico (IRCCS), Policlinico San Matteo, Pavia, Italy.
AD  - Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, Milan, 
      Italy.
FAU - Raineri, Claudia
AU  - Raineri C
AD  - Struttura Complessa Cardiologia, Fondazione Istituto Di Ricovero e Cura a 
      Carattere Scientifico (IRCCS), Policlinico San Matteo, Pavia, Italy.
FAU - Sirker, Alex
AU  - Sirker A
AD  - The National Institute of Health Research, University College London Hospitals, 
      Biomedical Research Centre, London, UK.
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Herrey, Anna S
AU  - Herrey AS
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
AD  - Royal Free Hospital, London, UK.
FAU - Manisty, Charlotte
AU  - Manisty C
AD  - The National Institute of Health Research, University College London Hospitals, 
      Biomedical Research Centre, London, UK.
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Groves, Ashley
AU  - Groves A
AD  - UCL Institute of Nuclear Medicine, University College London Hospital, London, 
      UK.
FAU - Moon, James C
AU  - Moon JC
AD  - The National Institute of Health Research, University College London Hospitals, 
      Biomedical Research Centre, London, UK.
AD  - Barts Heart Centre, St Bartholomew's Hospital, London, UK.
FAU - Hausenloy, Derek J
AU  - Hausenloy DJ
AD  - The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, 
      University College London, London, UK.
AD  - The National Institute of Health Research, University College London Hospitals, 
      Biomedical Research Centre, London, UK.
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 
      Singapore, Singapore.
AD  - Cardiovascular and Metabolic Disorders Program, Duke-National University of 
      Singapore, Singapore, Singapore.
AD  - Yong Loo Lin School of Medicine, National University Singapore, Singapore, 
      Singapore.
LA  - eng
GR  - FS/16/46/32187/BHF_/British Heart Foundation/United Kingdom
GR  - FS/10/039/28270/BHF_/British Heart Foundation/United Kingdom
GR  - CS/14/3/31002/BHF_/British Heart Foundation/United Kingdom
GR  - FS/10/72/28568/BHF_/British Heart Foundation/United Kingdom
GR  - FS/12/56/29723/BHF_/British Heart Foundation/United Kingdom
GR  - FS/10/40/28260/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
DEP - 20170313
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - ST Elevation Myocardial Infarction/*diagnostic imaging/physiopathology/therapy
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
PMC - PMC5346848
OTO - NOTNLM
OT  - LV ejection fraction
OT  - LV end-diastolic volume
OT  - LV end-systolic volume
OT  - LV remodeling, trabeculae and papillary muscles
OT  - ST-segment elevation myocardial infarction
OT  - infarct size, microvascular obstruction
EDAT- 2017/03/14 06:00
MHDA- 2017/12/13 06:00
PMCR- 2017/03/13
CRDT- 2017/03/14 06:00
PHST- 2016/10/11 00:00 [received]
PHST- 2017/02/16 00:00 [accepted]
PHST- 2017/03/14 06:00 [entrez]
PHST- 2017/03/14 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/03/13 00:00 [pmc-release]
AID - S1097-6647(23)01060-8 [pii]
AID - 343 [pii]
AID - 10.1186/s12968-017-0343-9 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2017 Mar 13;19(1):26. doi: 10.1186/s12968-017-0343-9.