PMID- 28285835
OWN - NLM
STAT- MEDLINE
DCOM- 20171011
LR  - 20210109
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 42
IP  - 8
DP  - 2017 Aug
TI  - Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.
PG  - 625-639
LID - S0968-0004(17)30042-7 [pii]
LID - 10.1016/j.tibs.2017.02.003 [doi]
AB  - Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human 
      pathologies. Therefore, a greater appreciation of the basic mechanisms of 
      mitochondrial gene expression is desirable to understand the pathophysiology of 
      associated disorders. Although the purpose of the mitochondrial gene expression 
      machinery is to provide only 13 proteins of the oxidative phosphorylation 
      (OxPhos) system, recent studies have revealed its remarkable and unexpected 
      complexity. We review here the latest breakthroughs in our understanding of the 
      post-transcriptional processes of mitochondrial gene expression, focusing on 
      advances in analyzing the mitochondrial epitranscriptome, the role of 
      mitochondrial RNA granules (MRGs), the benefits of recently obtained structures 
      of the mitochondrial ribosome, and the coordination of mitochondrial and 
      cytosolic translation to orchestrate the biogenesis of OxPhos complexes.
CI  - Crown Copyright (c) 2017. Published by Elsevier Ltd. All rights reserved.
FAU - Pearce, Sarah F
AU  - Pearce SF
AD  - Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology 
      Unit, Hills Road, Cambridge CB2 0XY, UK.
FAU - Rebelo-Guiomar, Pedro
AU  - Rebelo-Guiomar P
AD  - Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology 
      Unit, Hills Road, Cambridge CB2 0XY, UK; Graduate Program in Areas of Basic and 
      Applied Biology (GABBA), University of Porto, Porto, Portugal.
FAU - D'Souza, Aaron R
AU  - D'Souza AR
AD  - Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology 
      Unit, Hills Road, Cambridge CB2 0XY, UK.
FAU - Powell, Christopher A
AU  - Powell CA
AD  - Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology 
      Unit, Hills Road, Cambridge CB2 0XY, UK.
FAU - Van Haute, Lindsey
AU  - Van Haute L
AD  - Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology 
      Unit, Hills Road, Cambridge CB2 0XY, UK.
FAU - Minczuk, Michal
AU  - Minczuk M
AD  - Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology 
      Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: 
      michal.minczuk@mrc-mbu.cam.ac.uk.
LA  - eng
GR  - MC_U105697135/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_00015/4/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20170309
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/*genetics
MH  - Genes, Mitochondrial/*genetics
MH  - Humans
MH  - Mitochondria/*genetics/metabolism
MH  - Mitochondrial Ribosomes/chemistry/*metabolism
MH  - *Oxidative Phosphorylation
MH  - RNA Processing, Post-Transcriptional/genetics
PMC - PMC5538620
EDAT- 2017/03/14 06:00
MHDA- 2017/10/12 06:00
PMCR- 2017/08/01
CRDT- 2017/03/14 06:00
PHST- 2016/11/18 00:00 [received]
PHST- 2017/02/02 00:00 [revised]
PHST- 2017/02/10 00:00 [accepted]
PHST- 2017/03/14 06:00 [pubmed]
PHST- 2017/10/12 06:00 [medline]
PHST- 2017/03/14 06:00 [entrez]
PHST- 2017/08/01 00:00 [pmc-release]
AID - S0968-0004(17)30042-7 [pii]
AID - 10.1016/j.tibs.2017.02.003 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2017 Aug;42(8):625-639. doi: 10.1016/j.tibs.2017.02.003. Epub 
      2017 Mar 9.