PMID- 28286780
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2017
DP  - 2017
TI  - IL-1beta and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous 
      Subtype.
PG  - 5096741
LID - 10.1155/2017/5096741 [doi]
LID - 5096741
AB  - Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with 
      great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) 
      is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) 
      is associated with type I hypersensitivity. To better categorize SLE subtypes, we 
      determined the dominant cytokines based on familial SLE patients. Methods. RF, 
      IgE, and multiple cytokines (i.e., IL-1beta, IL-6, IL-8, IL-10, IL-17, IFN-gamma, IP-10, 
      MCP-1, and MIP-1beta) were measured in sera of familial SLE patients (n = 3), 
      noninherited SLE patients (n = 108), and healthy controls (n = 80). Results. 
      Three familial SLE patients and 5 noninherited SLE cases are with features of 
      RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of 
      IL-1beta and IL-6 than the other SLE patients (P < 0.05). IL-6 correlated with both 
      IgE and IL-1beta levels in RF+IgE+ SLE patients (r(2) = 0.583, P = 0.027; r(2) = 
      0.847, P = 0.001), and IgE also correlated with IL-1beta (r(2) = 0.567, P = 0.031). 
      Conclusion. Both IL-1beta and IL-6 are highly expressed cytokines in RF+IgE+ SLE 
      subtype which may be related to the pathogenesis of this special SLE subtype and 
      provide accurate treatment strategy by neutralizing IL-1beta and IL-6.
FAU - Wu, Yongkang
AU  - Wu Y
AUID- ORCID: 0000-0002-7352-3465
AD  - Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan 
      University, Chengdu, China.
FAU - Cai, Bei
AU  - Cai B
AUID- ORCID: 0000-0001-9872-6747
AD  - Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan 
      University, Chengdu, China.
FAU - Zhang, Junlong
AU  - Zhang J
AD  - Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan 
      University, Chengdu, China.
FAU - Shen, Beilei
AU  - Shen B
AD  - Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan 
      University, Chengdu, China.
FAU - Huang, Zhuochun
AU  - Huang Z
AD  - Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan 
      University, Chengdu, China.
FAU - Tan, Chunyu
AU  - Tan C
AD  - Department of Rheumatology, West China Hospital Affiliated to Sichuan University, 
      Chengdu, China.
FAU - Baan, Carla C
AU  - Baan CC
AD  - Department of Internal Medicine, Sector Nephrology & Transplantation, Erasmus MC, 
      Rotterdam, Netherlands.
FAU - Wang, Lanlan
AU  - Wang L
AUID- ORCID: 0000-0002-1640-7839
AD  - Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan 
      University, Chengdu, China.
LA  - eng
PT  - Journal Article
DEP - 20170212
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Interleukin-1beta/*blood
MH  - Interleukin-6/*blood
MH  - Lupus Erythematosus, Systemic/*diagnosis/genetics
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Phenotype
MH  - Rheumatoid Factor/*blood
MH  - Young Adult
PMC - PMC5329689
COIS- The authors report that there are no competing interests regarding the 
      publication of this paper.
EDAT- 2017/03/14 06:00
MHDA- 2017/03/28 06:00
PMCR- 2017/02/12
CRDT- 2017/03/14 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2016/12/14 00:00 [accepted]
PHST- 2017/03/14 06:00 [entrez]
PHST- 2017/03/14 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
PHST- 2017/02/12 00:00 [pmc-release]
AID - 10.1155/2017/5096741 [doi]
PST - ppublish
SO  - J Immunol Res. 2017;2017:5096741. doi: 10.1155/2017/5096741. Epub 2017 Feb 12.