PMID- 28287498 OWN - NLM STAT- MEDLINE DCOM- 20170619 LR - 20200306 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 14 IP - 3 DP - 2017 Mar 12 TI - Risk Factors for Mortality among Adult HIV/AIDS Patients Following Antiretroviral Therapy in Southwestern Ethiopia: An Assessment through Survival Models. LID - 10.3390/ijerph14030296 [doi] LID - 296 AB - Introduction: Efforts have been made to reduce HIV/AIDS-related mortality by delivering antiretroviral therapy (ART) treatment. However, HIV patients in resource-poor settings are still dying, even if they are on ART treatment. This study aimed to explore the factors associated with HIV/AIDS-related mortality in Southwestern Ethiopia. Method: A non-concurrent retrospective cohort study which collected data from the clinical records of adult HIV/AIDS patients, who initiated ART treatment and were followed between January 2006 and December 2010, was conducted, to explore the factors associated with HIV/AIDS-related mortality at Jimma University Specialized Hospital (JUSH). Survival times (i.e., the time from the onset of ART treatment to the death or censoring) and different characteristics of patients were retrospectively examined. A best-fit model was chosen for the survival data, after the comparison between native semi-parametric Cox regression and parametric survival models (i.e., exponential, Weibull, and log-logistic). Result: A total of 456 HIV patients were included in the study, mostly females (312, 68.4%), with a median age of 30 years (inter-quartile range (IQR): 23-37 years). Estimated follow-up until December 2010 accounted for 1245 person-years at risk (PYAR) and resulted in 66 (14.5%) deaths and 390 censored individuals, representing a median survival time of 34.0 months ( IQR: 22.8-42.0 months). The overall mortality rate was 5.3/100 PYAR: 6.5/100 PYAR for males and 4.8/100 PYAR for females. The Weibull survival model was the best model for fitting the data (lowest AIC). The main factors associated with mortality were: baseline age (>35 years old, AHR = 3.8, 95% CI: 1.6-9.1), baseline weight (AHR = 0.93, 95% CI: 0.90-0.97), baseline WHO stage IV (AHR = 6.2, 95% CI: 2.2-14.2), and low adherence to ART treatment (AHR = 4.2, 95% CI: 2.5-7.1). Conclusion: An effective reduction in HIV/AIDS mortality could be achieved through timely ART treatment onset and maintaining high levels of treatment adherence. FAU - Seyoum, Dinberu AU - Seyoum D AD - Institute of Health and Society (IRSS), Universite catholique de Louvain, Brussels B-1082, Belgium. dinberu.seyoum@gmail.com. AD - Department of Statistics, Natural Science College, Jimma University, Jimma, PO Box 378, Ethiopia. dinberu.seyoum@gmail.com. FAU - Degryse, Jean-Marie AU - Degryse JM AD - Institute of Health and Society (IRSS), Universite catholique de Louvain, Brussels B-1082, Belgium. Jean-Marie.Degryse@uclouvain.be. AD - Department Public Health and Primary Care, KU Leuven, Leuven B-3000, Belgium. Jean-Marie.Degryse@uclouvain.be. FAU - Kifle, Yehenew Getachew AU - Kifle YG AD - Department of Statistics and Operations Research, University of Limpopo, Sovenga, 0727, South Africa. yehenew.getachew@yahoo.com. FAU - Taye, Ayele AU - Taye A AD - School of Mathematical and Statistical Science, Hawassa University, P.O. Box 05, Ethiopia. ayele_taye@yahoo.com. FAU - Tadesse, Mulualem AU - Tadesse M AD - Department of Medical Laboratory Sciences and Pathology, College of Health Sciences, Jimma University, Jimma, P.O. Box 378, Ethiopia. mulualemt.tadesse@gmail.com. FAU - Birlie, Belay AU - Birlie B AD - Department of Statistics, Natural Science College, Jimma University, Jimma, PO Box 378, Ethiopia. belaya.birlie@gmail.com. FAU - Banbeta, Akalu AU - Banbeta A AD - Department of Statistics, Natural Science College, Jimma University, Jimma, PO Box 378, Ethiopia. akalubanbeta.stat@gmail.com. FAU - Rosas-Aguirre, Angel AU - Rosas-Aguirre A AD - Institute of Health and Society (IRSS), Universite catholique de Louvain, Brussels B-1082, Belgium. angelrosasa@gmail.com. AD - Institute of Tropical Medicine "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima 15000, Peru. angelrosasa@gmail.com. FAU - Duchateau, Luc AU - Duchateau L AD - Department of Comparative Physiology and Biometrics, Ghent University, Ghent B-9000, Belgium. luc.duchateau@ugent.be. FAU - Speybroeck, Niko AU - Speybroeck N AD - Institute of Health and Society (IRSS), Universite catholique de Louvain, Brussels B-1082, Belgium. niko.speybroeck@uclouvain.be. LA - eng PT - Journal Article DEP - 20170312 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Anti-HIV Agents) SB - IM MH - Adult MH - Anti-HIV Agents/*therapeutic use MH - Ethiopia/epidemiology MH - Female MH - HIV Infections/*drug therapy/*mortality MH - Hospitals, University MH - Humans MH - Male MH - Retrospective Studies MH - Risk Factors MH - Survival Analysis MH - Young Adult PMC - PMC5369132 OTO - NOTNLM OT - Ethiopia OT - HIV/AIDS OT - antiretroviral therapy (ART) OT - parametric survival model COIS- The authors declare that they have no conflicting interests. EDAT- 2017/03/14 06:00 MHDA- 2017/06/20 06:00 PMCR- 2017/03/01 CRDT- 2017/03/14 06:00 PHST- 2017/01/15 00:00 [received] PHST- 2017/02/27 00:00 [revised] PHST- 2017/03/09 00:00 [accepted] PHST- 2017/03/14 06:00 [entrez] PHST- 2017/03/14 06:00 [pubmed] PHST- 2017/06/20 06:00 [medline] PHST- 2017/03/01 00:00 [pmc-release] AID - ijerph14030296 [pii] AID - ijerph-14-00296 [pii] AID - 10.3390/ijerph14030296 [doi] PST - epublish SO - Int J Environ Res Public Health. 2017 Mar 12;14(3):296. doi: 10.3390/ijerph14030296.