PMID- 28288039
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20170913
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 41
IP  - 7
DP  - 2017 Jul
TI  - LMO2-negative Expression Predicts the Presence of MYC Translocations in 
      Aggressive B-Cell Lymphomas.
PG  - 877-886
LID - 10.1097/PAS.0000000000000839 [doi]
AB  - MYC translocation is a defining feature of Burkitt lymphoma (BL), and the new 
      category of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 
      translocations, and occurs in 6% to 15% of diffuse large B-cell lymphomas 
      (DLBCLs). The low incidence of MYC translocations in DLBCL makes the genetic 
      study of all these lymphomas cumbersome. Strategies based on an initial 
      immunophenotypic screening to select cases with a high probability of carrying 
      the translocation may be useful. LMO2 is a germinal center marker expressed in 
      most lymphomas originated in these cells. Mining gene expression profiling 
      studies, we observed LMO2 downregulation in BL and large B-cell lymphoma (LBCL) 
      with MYC translocations, and postulated that LMO2 protein expression could assist 
      to identify such cases. We analyzed LMO2 protein expression in 46 BLs and 284 
      LBCL. LMO2 was expressed in 1/46 (2%) BL cases, 146/268 (54.5%) DLBCL cases, and 
      2/16 (12.5%) high-grade B-cell lymphoma cases with MYC and BCL2 and/or BCL6 
      translocations. All BLs carried MYC translocation (P<0.001), whereas LMO2 was 
      only positive in 6/42 (14%) LBCL with MYC translocation (P<0.001). The 
      relationship between LMO2 negativity and MYC translocation was further analyzed 
      in different subsets of tumors according to CD10 expression and cell of origin. 
      Lack of LMO2 expression was associated with the detection of MYC translocations 
      with high sensitivity (87%), specificity (87%), positive predictive value and 
      negative predictive value (74% and 94%, respectively), and accuracy (87%) in CD10 
      LBCL. Comparing LMO2 and MYC protein expression, all statistic measures of 
      performance of LMO2 surpassed MYC in CD10 LBCL. These findings suggest that LMO2 
      loss may be a good predictor for the presence of MYC translocation in CD10 LBCL.
FAU - Colomo, Luis
AU  - Colomo L
AD  - *Department of Pathology, Hematopathology Unit, Hospital del Mar, Institute of 
      Investigacions Mediques-IMIM, University Pompeu Fabra daggerDepartment of Pathology, 
      Hematopathology Section, Hospital Clinic, Institute of Investigacions Biomediques 
      Agust Pi Sunyer (IDIBAPS), University of Barcelona double daggerDepartment of Pathology, 
      Hospital de Bellvitge-IDIBELL, Hospitalet de Llobregat  paragraph signDepartment of Pathology, 
      Hospital de Sant Pau #Microarray Analysis Service, Institute of Investigacions 
      Mediques-IMIM, Barcelona  section signDepartment of Pathology, Hospital Germans Trias i 
      Pujol, Badalona  parallelDepartment of Pathology, Hospital Mutua Terrassa, Terrassa, 
      Spain **Institute of Pathology, Locarno, Switzerland.
FAU - Vazquez, Ivonne
AU  - Vazquez I
FAU - Papaleo, Natalia
AU  - Papaleo N
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Ferrer, Anna
AU  - Ferrer A
FAU - Franco, Catalina
AU  - Franco C
FAU - Comerma, Laura
AU  - Comerma L
FAU - Hernandez, Silvia
AU  - Hernandez S
FAU - Calvo, Xavier
AU  - Calvo X
FAU - Salar, Antonio
AU  - Salar A
FAU - Climent, Fina
AU  - Climent F
FAU - Mate, Jose Luis
AU  - Mate JL
FAU - Forcada, Pilar
AU  - Forcada P
FAU - Mozos, Anna
AU  - Mozos A
FAU - Nonell, Lara
AU  - Nonell L
FAU - Martinez, Antonio
AU  - Martinez A
FAU - Carrio, Anna
AU  - Carrio A
FAU - Costa, Dolors
AU  - Costa D
FAU - Dlouhy, Ivan
AU  - Dlouhy I
FAU - Salaverria, Itziar
AU  - Salaverria I
FAU - Martin-Subero, Jose Ignacio
AU  - Martin-Subero JI
FAU - Lopez-Guillermo, Armando
AU  - Lopez-Guillermo A
FAU - Valera, Alexandra
AU  - Valera A
FAU - Campo, Elias
AU  - Campo E
CN  - Grup per l'Estudi dels Limfomes de Catalunya i Balears (GELCAB)
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (LMO2 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
EIN - Am J Surg Pathol. 2019 Mar;43(3):434. PMID: 30724749
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Burkitt Lymphoma/genetics/*metabolism/pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genes, myc
MH  - Humans
MH  - Immunohistochemistry
MH  - LIM Domain Proteins/*metabolism
MH  - Lymphoma, Large B-Cell, Diffuse/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Retrospective Studies
MH  - *Translocation, Genetic
MH  - Young Adult
EDAT- 2017/03/14 06:00
MHDA- 2017/09/14 06:00
CRDT- 2017/03/14 06:00
PHST- 2017/03/14 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
PHST- 2017/03/14 06:00 [entrez]
AID - 10.1097/PAS.0000000000000839 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2017 Jul;41(7):877-886. doi: 10.1097/PAS.0000000000000839.