PMID- 28288284
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 42
IP  - 8
DP  - 2017 Aug
TI  - Sweet potato (Ipomoea batatas) attenuates diet-induced aortic stiffening 
      independent of changes in body composition.
PG  - 802-809
LID - 10.1139/apnm-2016-0571 [doi]
AB  - We hypothesized a sweet potato intervention would prevent high-fat (HF) 
      diet-induced aortic stiffness, which would be associated with decreased arterial 
      oxidative stress and increased mitochondrial uncoupling. Young (8-week old) 
      C57BL/6J mice were randomly divided into 4 groups: low fat (LF; 10% fat), HF (60% 
      fat), low-fat sweet potato (LFSP; 10% fat containing 260.3 mug/kcal sweet potato), 
      or high-fat sweet potato diet (HFSP; 60% fat containing 260.3 mug/kcal sweet 
      potato) for 16 weeks. Compared with LF and LFSP, HF- and HFSP-fed mice had 
      increased body mass and percent fat mass with lower percent lean mass (all, P < 
      0.05). Sweet potato intervention did not influence body composition (all, P > 
      0.05). Arterial stiffness, assessed by aortic pulse wave velocity and ex vivo 
      mechanical testing of the elastin region elastic modulus (EEM) was greater in HF 
      compared with LF and HFSP animals (all, P < 0.05). Advanced glycation end 
      products and nitrotyrosine abundance were greater in aortic segments from HF mice 
      compared with LF and HFSP animals (all, P < 0.05). Aortic elastin and uncoupling 
      protein 2 expressions, however, were reduced in HF compared with LF and HFSP mice 
      (all, P < 0.05). Aortic segments cultured with 2,4-dinitrophenol (DNP), a 
      mitochondrial uncoupler, for 72 h reduced the EEM of HF arteries compared with 
      nontreated HF segments (P < 0.05). DNP had no effect on the EEM of aortic 
      segments from HFSP mice. In conclusion, sweet potato attenuates diet-induced 
      aortic stiffness independent of body mass and composition, which is associated 
      with a normalization of arterial oxidative stress possibly due to mitochondrial 
      uncoupling.
FAU - Garner, Tyler
AU  - Garner T
AD  - a Department of Kinesiology and Health Promotion, University of Kentucky, 
      Lexington, KY 40506, USA.
FAU - Ouyang, An
AU  - Ouyang A
AD  - a Department of Kinesiology and Health Promotion, University of Kentucky, 
      Lexington, KY 40506, USA.
FAU - Berrones, Adam J
AU  - Berrones AJ
AD  - a Department of Kinesiology and Health Promotion, University of Kentucky, 
      Lexington, KY 40506, USA.
FAU - Campbell, Marilyn S
AU  - Campbell MS
AD  - a Department of Kinesiology and Health Promotion, University of Kentucky, 
      Lexington, KY 40506, USA.
FAU - Du, Bing
AU  - Du B
AD  - b Department of Cardiology, The First Hospital of Jilin University, Changchun 
      130000, China.
FAU - Fleenor, Bradley S
AU  - Fleenor BS
AD  - a Department of Kinesiology and Health Promotion, University of Kentucky, 
      Lexington, KY 40506, USA.
LA  - eng
PT  - Journal Article
DEP - 20170313
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
SB  - IM
MH  - Animals
MH  - Aorta/metabolism
MH  - Blood Pressure
MH  - *Body Composition
MH  - Body Mass Index
MH  - Diet, High-Fat/*adverse effects
MH  - *Ipomoea batatas
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Biological
MH  - Oxidative Stress
MH  - Pulse Wave Analysis
MH  - *Vascular Stiffness
OTO - NOTNLM
OT  - 2,4-dinitrophenol
OT  - 2,4-dinitrophenol
OT  - mitochondria
OT  - mitochondrie
OT  - obesity
OT  - obesite
OT  - proteines de decouplage
OT  - uncoupling proteins
EDAT- 2017/03/14 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/03/14 06:00
PHST- 2017/03/14 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/03/14 06:00 [entrez]
AID - 10.1139/apnm-2016-0571 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2017 Aug;42(8):802-809. doi: 10.1139/apnm-2016-0571. 
      Epub 2017 Mar 13.