PMID- 28288621
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20221207
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 16
IP  - 1
DP  - 2017 Mar 14
TI  - Relationship between plasma homocysteine level and lipid profiles in a 
      community-based Chinese population.
PG  - 54
LID - 10.1186/s12944-017-0441-6 [doi]
LID - 54
AB  - BACKGROUND: Previous studies established a possible link among 
      hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. However, there 
      was limited epidemic data concerning the relation between HHcy and lipid 
      profiles, especially in community-based Chinese populations. This study aim to 
      investigate the association of plasma homocysteine (Hcy) level with lipid 
      profiles in a Chinese community-based population without lipid-lowering 
      treatment. METHOD: A total of 4660 Chinese subjects from a cohort of the 
      Shijingshan district in Beijing were included in the analysis. Plasma total Hcy, 
      serum lipid files including total cholesterol (TC), triglycerides (TG), 
      low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol 
      (HDL-C) as well as relevant metabolic risk factors were measured. Multivariate 
      regression models adjusting for age, gender, smoking, drinking, physical 
      activity, vitamin B supplement, body mass index, fasting blood glucose level, 
      serum creatinine, systolic and diastolic blood pressure were used to evaluate 
      associations of Hcy and lipid profiles. RESULT: Subjects were 56.75 +/- 8.91 years 
      old, and 38.15% were male. Median (IQR) Hcy was 11.98 (10.00-14.93) mumol/L, and 
      24.4% had HHcy (defined as Hcy >/= 15 mumol/L). Mean (SD) baseline TC was 
      5.34 +/- 0.98 mmol/L, LDL-C was 3.27 +/- 0.81 mmol/L, and HDL-C was 
      1.43 +/- 0.38 mmol/L. Median (IQR) of TG was 1.28 (0.91-1.85) mmol/L. In 
      multivariable linear-regression analyses, lnHcy (ln transformation for Hcy) level 
      was positively associated with lnTG (adjusted beta = 0.075, SE = 0.021, P = 0.001). 
      Using Hcy < 15 mumol/L as a reference, HHcy was independently associated with both 
      lnTG (adjusted beta = 0.056, SE = 0.020, P = 0.004) and lnHDL (adjusted beta = -0.018, 
      SE = 0.009, P = 0.038). In multivariable logistic-regression analyses, HHcy was 
      associated with increasing risk of low HDL-C (HDL-C < 1.04 mmol/L; adjusted odds 
      ratio [OR] =1.406, 95% confidence interval [CI]: 1.143 - 1.728, P = 0.001) and 
      hypertriglyceridemia (TG >/= 1.7 mmol/L; adjusted OR = 1.293, 95% CI: 1.096-1.524, 
      P = 0.002) after adjusting the confounders. However, there were no significant 
      associations between Hcy and TC or LDL-C. CONCLUSION: The present study showed 
      that HHcy was independently associated with hypertriglyceridemia and low levels 
      of HDL-C, which provides evidence that Hcy levels might affect HDL-C and TG 
      metabolism.
FAU - Momin, Mohetaboer
AU  - Momin M
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China.
FAU - Jia, Jia
AU  - Jia J
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China.
FAU - Fan, Fangfang
AU  - Fan F
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China.
FAU - Li, Jianping
AU  - Li J
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China.
FAU - Dou, Jingtao
AU  - Dou J
AD  - Department of Endocrinology, Chinese People's Liberation Army (PLA) General 
      Hospital, Beijing, China.
FAU - Chen, Dafang
AU  - Chen D
AD  - Department of Epidemic & Biostatistics, School of Public Health, Peking 
      University Health Science Center, Beijing, China.
FAU - Huo, Yong
AU  - Huo Y
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China. 
      drzhy1108@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipids)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Asian People
MH  - Beijing
MH  - Biomarkers/blood
MH  - Cholesterol, HDL/blood
MH  - Cohort Studies
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hypertriglyceridemia/blood
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
PMC - PMC5348889
OTO - NOTNLM
OT  - High-density lipoprotein cholesterol
OT  - Homocysteine
OT  - Triglycerides
EDAT- 2017/03/16 06:00
MHDA- 2017/05/16 06:00
PMCR- 2017/03/14
CRDT- 2017/03/15 06:00
PHST- 2016/08/10 00:00 [received]
PHST- 2017/03/02 00:00 [accepted]
PHST- 2017/03/15 06:00 [entrez]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2017/03/14 00:00 [pmc-release]
AID - 10.1186/s12944-017-0441-6 [pii]
AID - 441 [pii]
AID - 10.1186/s12944-017-0441-6 [doi]
PST - epublish
SO  - Lipids Health Dis. 2017 Mar 14;16(1):54. doi: 10.1186/s12944-017-0441-6.