PMID- 28289224 OWN - NLM STAT- MEDLINE DCOM- 20180709 LR - 20240325 IS - 1091-6490 (Electronic) IS - 0027-8424 (Print) IS - 0027-8424 (Linking) VI - 114 IP - 13 DP - 2017 Mar 28 TI - Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion. PG - 3527-3532 LID - 10.1073/pnas.1620928114 [doi] AB - During adolescence, the human cortex undergoes substantial remodeling to support a rapid expansion of behavioral repertoire. Accurately quantifying these changes is a prerequisite for understanding normal brain development, as well as the neuropsychiatric disorders that emerge in this vulnerable period. Past accounts have demonstrated substantial regional heterogeneity in patterns of brain development, but frequently have been limited by small samples and analytics that do not evaluate complex multivariate imaging patterns. Capitalizing on recent advances in multivariate analysis methods, we used nonnegative matrix factorization (NMF) to uncover coordinated patterns of cortical development in a sample of 934 youths ages 8-20, who completed structural neuroimaging as part of the Philadelphia Neurodevelopmental Cohort. Patterns of structural covariance (PSCs) derived by NMF were highly reproducible over a range of resolutions, and differed markedly from common gyral-based structural atlases. Moreover, PSCs were largely symmetric and showed correspondence to specific large-scale functional networks. The level of correspondence was ordered according to their functional role and position in the evolutionary hierarchy, being high in lower-order visual and somatomotor networks and diminishing in higher-order association cortex. Furthermore, PSCs showed divergent developmental associations, with PSCs in higher-order association cortex networks showing greater changes with age than primary somatomotor and visual networks. Critically, such developmental changes within PSCs were significantly associated with the degree of evolutionary cortical expansion. Together, our findings delineate a set of structural brain networks that undergo coordinated cortical thinning during adolescence, which is in part governed by evolutionary novelty and functional specialization. FAU - Sotiras, Aristeidis AU - Sotiras A AUID- ORCID: 0000-0003-0795-8820 AD - Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; aristeidis.sotiras@uphs.upenn.edu. AD - Department of Radiology, Section of Biomedical Image Analysis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. FAU - Toledo, Jon B AU - Toledo JB AD - Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. AD - Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. AD - Department of Neurology, Houston Methodist Neurological Institute, Houston, TX 77030. FAU - Gur, Raquel E AU - Gur RE AD - Department of Psychiatry, Neuropsychiatry Section and the Brain Behavior Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. FAU - Gur, Ruben C AU - Gur RC AD - Department of Psychiatry, Neuropsychiatry Section and the Brain Behavior Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. FAU - Satterthwaite, Theodore D AU - Satterthwaite TD AD - Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. AD - Department of Psychiatry, Neuropsychiatry Section and the Brain Behavior Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. FAU - Davatzikos, Christos AU - Davatzikos C AD - Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. AD - Department of Radiology, Section of Biomedical Image Analysis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. LA - eng GR - P50 MH096891/MH/NIMH NIH HHS/United States GR - R01 EB022573/EB/NIBIB NIH HHS/United States GR - R01 MH107235/MH/NIMH NIH HHS/United States GR - R01 MH112070/MH/NIMH NIH HHS/United States GR - R01 MH101111/MH/NIMH NIH HHS/United States GR - RC2 MH089924/MH/NIMH NIH HHS/United States GR - R01 NS042645/NS/NINDS NIH HHS/United States GR - R01 MH107703/MH/NIMH NIH HHS/United States GR - RC2 MH089983/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20170313 PL - United States TA - Proc Natl Acad Sci U S A JT - Proceedings of the National Academy of Sciences of the United States of America JID - 7505876 SB - IM MH - Adolescent MH - Brain/diagnostic imaging/growth & development/physiology MH - Cerebral Cortex/diagnostic imaging/*growth & development/*physiology MH - Child MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Neuroimaging MH - Young Adult PMC - PMC5380071 OTO - NOTNLM OT - MRI OT - cortical organization OT - cortical thickness OT - development OT - nonnegative matrix factorization COIS- The authors declare no conflict of interest. EDAT- 2017/03/16 06:00 MHDA- 2018/07/10 06:00 PMCR- 2017/09/28 CRDT- 2017/03/15 06:00 PHST- 2017/03/16 06:00 [pubmed] PHST- 2018/07/10 06:00 [medline] PHST- 2017/03/15 06:00 [entrez] PHST- 2017/09/28 00:00 [pmc-release] AID - 1620928114 [pii] AID - 201620928 [pii] AID - 10.1073/pnas.1620928114 [doi] PST - ppublish SO - Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3527-3532. doi: 10.1073/pnas.1620928114. Epub 2017 Mar 13.