PMID- 28289586
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240325
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 19
IP  - 2
DP  - 2016 Dec 1
TI  - Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy 
      in Caucasians with type 2 diabetes mellitus.
PG  - 29-34
LID - 10.1515/bjmg-2016-0033 [doi]
AB  - Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) 
      in developed countries. Several environmental and genetic factors predict the 
      development and progression of DN. The renin-angiotensin system was demonstrated 
      to be involved in the development of DN. We evaluated the association between 
      rs4340 of the angiotensin-converting enzyme (ACE) gene and DN in Caucasians with 
      type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, 
      and 375 patients without clinical signs of DN. Genetic analysis was performed 
      with either standard polymerase chain reaction (PCR) (for rs4340). Results were 
      analyzed using the chi(2) test and multivariate logistic regression analyses. We 
      found no association between rs4340 and DN. Cystatin C was significantly higher 
      in the DN+ group (p <0.001) than in the DN group. Cystatin C was a better marker 
      for the estimation of renal function than estimated glomerular filtration rate 
      (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ 
      min. We concluded that there was no association between the rs4340 of the ACE 
      gene and DN in Caucasian patients who have T2DM.
FAU - Seruga, M
AU  - Seruga M
AD  - Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, 
      Slovenia.
FAU - Makuc, J
AU  - Makuc J
AD  - Department of Internal Medicine, General Hospital Slovenj Gradec, Slovenj Gradec, 
      Slovenia.
FAU - Zavrsnik, M
AU  - Zavrsnik M
AD  - Department of Endocrinology and Diabetology, University Medical Centre Maribor, 
      Division of Internal Medicine, Maribor, Slovenia.
FAU - Cilensek, I
AU  - Cilensek I
AD  - Institute of Histology and Embryology, Faculty of Medicine, University of 
      Ljubljana, Ljubljana, Slovenia.
FAU - Ekart, R
AU  - Ekart R
AD  - Department of Haemodialysis, University Medical Centre Maribor, Division of 
      Internal Medicine, Maribor, Slovenia.
FAU - Petrovic, D
AU  - Petrovic D
AD  - Institute of Histology and Embryology, Faculty of Medicine, University of 
      Ljubljana, Ljubljana, Slovenia.
LA  - eng
PT  - Journal Article
DEP - 20170304
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC5343328
OTO - NOTNLM
OT  - Angiotensin-converting enzyme (ACE)
OT  - Diabetic nephropathy
OT  - Insertion/deletion (I/D) gene polymorphism
OT  - Type 2 diabetes mellitus (T2DM)
COIS- The authors report no conflicts of interest. The authors alone are responsible 
      for the content and writing of this article.
EDAT- 2017/03/16 06:00
MHDA- 2017/03/16 06:01
PMCR- 2016/12/31
CRDT- 2017/03/15 06:00
PHST- 2017/03/15 06:00 [entrez]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/03/16 06:01 [medline]
PHST- 2016/12/31 00:00 [pmc-release]
AID - bjmg-2016-0033 [pii]
AID - 10.1515/bjmg-2016-0033 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2017 Mar 4;19(2):29-34. doi: 10.1515/bjmg-2016-0033. 
      eCollection 2016 Dec 1.