PMID- 28289991 OWN - NLM STAT- MEDLINE DCOM- 20180105 LR - 20181113 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 33 IP - 8 DP - 2017 Aug TI - Quantitative analysis of late gadolinium enhancement in hypertrophic cardiomyopathy: comparison of diagnostic performance in myocardial fibrosis between gadobutrol and gadopentetate dimeglumine. PG - 1191-1200 LID - 10.1007/s10554-017-1101-7 [doi] AB - The purpose of this study was to compare different semi-automated late gadolinium enhancement (LGE) quantification techniques using gadobutrol and gadopentetate dimeglumine contrast agents with regard to the diagnosis of fibrotic myocardium in patients with hypertrophic cardiomyopathy (HCM). Thirty patients with HCM underwent two cardiac MRI protocols with use of gadobutrol and gadopentetate dimeglumine. Contrast-to-noise ratio (CNR) between LGE area and remote myocardium (CNRremote), between LGE area and left ventricular blood pool (CNRpool), and signal-to-noise ratio (SNR) in LGE were compared. The presence and quantity of LGE were determined by visual assessment. With signal threshold versus reference mean (STRM) based thresholds of 2 SD, 5 SD, and 6 SD above the mean signal intensity (SI) of reference myocardium, the full-width at half-maximum (FWHM) technique was used. The volume and segments of the LGE area were compared between the two types of contrast agents. LGE was present in 26 of 30 (86.6%) patients in both protocols. The CNRremote of fibrotic myocardium in gadobutrol and gadopentetate dimeglumine agents was 26.82 +/- 14.24 and 21.46 +/- 10.59, respectively (P < 0.05). The CNRpool was significantly higher in gadobutrol (9.32 +/- 7.64 vs. 6.39 +/- 6.11, P < 0.05). The SNR was higher in gadobutrol (33.36 +/- 14.35 vs. 27.53 +/- 10.91, P < 0.05). The volume of scar size in MR images acquired with gadobutrol were significantly higher than those with gadopentetate dimeglumine (P < 0.05), and the STRM of 5 SD technique showed the greatest agreement with visual assessment (ICC = 0.99) in both examinations. There was no significant difference in fibrotic segments of the fibrotic myocardium in the LGE area (P < 0.05). This study proved that the Gadobutrol was an effective contrast agent for LGE imaging with superior delineation of fibrotic myocardium as compared to gadopentetate dimeglumine. The 5 SD technique yields the closest approximation of the extent of LGE identified by visual assessment. FAU - Liu, Dongting AU - Liu D AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. FAU - Ma, Xiaohai AU - Ma X AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. maxi8238@yahoo.com. FAU - Liu, Jiayi AU - Liu J AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. FAU - Zhao, Lei AU - Zhao L AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. FAU - Chen, Hui AU - Chen H AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. FAU - Xu, Lei AU - Xu L AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. FAU - Sun, Zhonghua AU - Sun Z AD - Department of Medical Radiation Sciences, Curtin University, Perth, 6102, Australia. FAU - Fan, Zhanming AU - Fan Z AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, China. fanzm120@126.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20170313 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Automation MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging/pathology MH - Contrast Media/*administration & dosage MH - Female MH - Fibrosis MH - Gadolinium DTPA/*administration & dosage MH - Humans MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Organometallic Compounds/*administration & dosage MH - Predictive Value of Tests MH - Reproducibility of Results MH - Signal-To-Noise Ratio OTO - NOTNLM OT - Cardiovascular magnetic resonance (CMR) OT - Contrast agent OT - Gadobutrol OT - Gadopentetate dimeglumine OT - Hypertrophic cardiomyopathy (HCM) OT - Late gadolinium enhancement (LGE) EDAT- 2017/03/16 06:00 MHDA- 2018/01/06 06:00 CRDT- 2017/03/15 06:00 PHST- 2016/09/29 00:00 [received] PHST- 2017/02/24 00:00 [accepted] PHST- 2017/03/16 06:00 [pubmed] PHST- 2018/01/06 06:00 [medline] PHST- 2017/03/15 06:00 [entrez] AID - 10.1007/s10554-017-1101-7 [pii] AID - 10.1007/s10554-017-1101-7 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2017 Aug;33(8):1191-1200. doi: 10.1007/s10554-017-1101-7. Epub 2017 Mar 13.