PMID- 28291393 OWN - NLM STAT- MEDLINE DCOM- 20170913 LR - 20170913 IS - 1527-7755 (Electronic) IS - 0732-183X (Linking) VI - 35 IP - 16 DP - 2017 Jun 1 TI - Early Positron Emission Tomography Response-Adapted Treatment in Stage I and II Hodgkin Lymphoma: Final Results of the Randomized EORTC/LYSA/FIL H10 Trial. PG - 1786-1794 LID - 10.1200/JCO.2016.68.6394 [doi] AB - Purpose Patients who receive combined modality treatment for stage I and II Hodgkin lymphoma (HL) have an excellent outcome. Early response evaluation with positron emission tomography (PET) scan may improve selection of patients who need reduced or more intensive treatments. Methods We performed a randomized trial to evaluate treatment adaptation on the basis of early PET (ePET) after two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) in previously untreated-according to European Organisation for Research and Treatment of Cancer criteria favorable (F) and unfavorable (U)-stage I and II HL. The standard arm consisted of ABVD followed by involved-node radiotherapy (INRT), regardless of ePET result. In the experimental arm, ePET-negative patients received ABVD only (noninferiority design), whereas ePET-positive patients switched to two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPPesc) and INRT (superiority design). Primary end point was progression-free survival (PFS). Results Of 1,950 randomly assigned patients, 1,925 received an ePET-361 patients (18.8%) were positive. In ePET-positive patients, 5-year PFS improved from 77.4% for standard ABVD + INRT to 90.6% for intensification to BEACOPPesc + INRT (hazard ratio [HR], 0.42; 95% CI, 0.23 to 0.74; P = .002). In ePET-negative patients, 5-year PFS rates in the F group were 99.0% versus 87.1% (HR, 15.8; 95% CI, 3.8 to 66.1) in favor of ABVD + INRT; the U group, 92.1% versus 89.6% (HR, 1.45; 95% CI, 0.8 to 2.5) in favor of ABVD + INRT. For both F and U groups, noninferiority of ABVD only compared with combined modality treatment could not be demonstrated. Conclusion In stage I and II HL, PET response after two cycles of ABVD allows for early treatment adaptation. When ePET is positive after two cycles of ABVD, switching to BEACOPPesc + INRT significantly improved 5-year PFS. In ePET-negative patients, noninferiority of ABVD only could not be demonstrated: risk of relapse is increased when INRT is omitted, especially in patients in the F group. FAU - Andre, Marc P E AU - Andre MPE AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Girinsky, Theodore AU - Girinsky T AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Federico, Massimo AU - Federico M AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Reman, Oumedaly AU - Reman O AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Fortpied, Catherine AU - Fortpied C AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Gotti, Manuel AU - Gotti M AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Casasnovas, Olivier AU - Casasnovas O AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Brice, Pauline AU - Brice P AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - van der Maazen, Richard AU - van der Maazen R AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Re, Alessandro AU - Re A AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Edeline, Veronique AU - Edeline V AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Ferme, Christophe AU - Ferme C AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - van Imhoff, Gustaaf AU - van Imhoff G AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Merli, Francesco AU - Merli F AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Bouabdallah, Reda AU - Bouabdallah R AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Sebban, Catherine AU - Sebban C AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Specht, Lena AU - Specht L AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Stamatoullas, Aspasia AU - Stamatoullas A AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Delarue, Richard AU - Delarue R AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Fiaccadori, Valeria AU - Fiaccadori V AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Bellei, Monica AU - Bellei M AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Raveloarivahy, Tiana AU - Raveloarivahy T AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Versari, Annibale AU - Versari A AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Hutchings, Martin AU - Hutchings M AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Meignan, Michel AU - Meignan M AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Raemaekers, John AU - Raemaekers J AD - Marc P.E. Andre, Universite Catholique de Louvain, Yvoir; Catherine Fortpied, Valeria Fiaccadori, and Tiana Raveloarivahy, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Theodore Girinsky and Christophe Ferme, Institut Gustave Roussy, Villejuif; Oumedaly Reman, Institut d'Hematologie de Basse Normandie, Centre Hospitalier Universitaire, Caen; Pauline Brice, Assistance Publique des Hopitaux de Paris Hopital Saint-Louis; Richard Delarue, Assistance Publique des Hopitaux de Paris Hopital Universitaire Necker-Enfants Maladies, Paris; Olivier Casasnovas, Centre Hospitalier Universitaire le Bocage and Institut National de la Sante et de la Recherche Medicale, Dijon; Veronique Edeline, Hopital Rene Hugenin-Institut Curie, Saint Cloud; Reda Bouabdallah, Institut Paoli Calmette, Marseille; Catherine Sebban, Hematology Centre Leon Berard, Lyon; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Michel Meignan, Henri Mondor University Hospitals, Creteil, France; Massimo Federico and Monica Bellei, University of Modena and Reggio Emilia, Modena; Manuel Gotti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia; Alessandro Re, Spedali Civili Hospital, Brescia; Francesco Merli and Annibale Versari, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Richard van der Maazen and John Raemaekers, Radboud University Medical Center, Nijmegen; Gustaaf van Imhoff, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; and Lena Specht and Martin Hutchings, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. LA - eng PT - Clinical Trial, Phase III PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20170314 PL - United States TA - J Clin Oncol JT - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JID - 8309333 RN - 11056-06-7 (Bleomycin) RN - 35S93Y190K (Procarbazine) RN - 5J49Q6B70F (Vincristine) RN - 5V9KLZ54CY (Vinblastine) RN - 6PLQ3CP4P3 (Etoposide) RN - 7GR28W0FJI (Dacarbazine) RN - 80168379AG (Doxorubicin) RN - 8N3DW7272P (Cyclophosphamide) RN - VB0R961HZT (Prednisone) RN - ABVD protocol RN - BEACOPP protocol SB - IM CIN - J Clin Oncol. 2017 Jun 1;35(16):1760-1763. PMID: 28368671 CIN - J Clin Oncol. 2017 Aug 20;35(24):2853-2854. PMID: 28682682 CIN - J Clin Oncol. 2017 Aug 20;35(24):2850-2851. PMID: 28682684 CIN - J Clin Oncol. 2017 Aug 20;35(24):2852. PMID: 28682685 CIN - J Clin Oncol. 2017 Aug 20;35(24):2854-2855. PMID: 28682688 CIN - J Clin Oncol. 2017 Aug 20;35(24):2851-2852. PMID: 28682690 CIN - J Clin Oncol. 2017 Aug 20;35(24):2849-2850. PMID: 28682691 CIN - Int J Radiat Oncol Biol Phys. 2020 May 1;107(1):12-17. PMID: 32142868 MH - Adolescent MH - Adult MH - Aged MH - Antineoplastic Combined Chemotherapy Protocols/administration & dosage/*therapeutic use MH - Bleomycin/administration & dosage MH - Chemoradiotherapy MH - Cyclophosphamide/administration & dosage MH - Dacarbazine/administration & dosage MH - Disease-Free Survival MH - Doxorubicin/administration & dosage MH - Etoposide/administration & dosage MH - Female MH - Hodgkin Disease/*diagnostic imaging/*drug therapy/pathology/radiotherapy MH - Humans MH - Male MH - Middle Aged MH - Neoplasm Staging MH - Positron-Emission Tomography/methods MH - Prednisone/administration & dosage MH - Procarbazine/administration & dosage MH - Survival Rate MH - Vinblastine/administration & dosage MH - Vincristine/administration & dosage MH - Young Adult EDAT- 2017/03/16 06:00 MHDA- 2017/09/14 06:00 CRDT- 2017/03/15 06:00 PHST- 2017/03/16 06:00 [pubmed] PHST- 2017/09/14 06:00 [medline] PHST- 2017/03/15 06:00 [entrez] AID - 10.1200/JCO.2016.68.6394 [doi] PST - ppublish SO - J Clin Oncol. 2017 Jun 1;35(16):1786-1794. doi: 10.1200/JCO.2016.68.6394. Epub 2017 Mar 14.