PMID- 28291591 OWN - NLM STAT- MEDLINE DCOM- 20171127 LR - 20180126 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 220 IP - 4 DP - 2017 Jun TI - The INMA-INfancia y Medio Ambiente-(Environment and Childhood) project: More than 10 years contributing to environmental and neuropsychological research. PG - 647-658 LID - S1438-4639(16)30635-6 [pii] LID - 10.1016/j.ijheh.2017.02.008 [doi] AB - BACKGROUND: In 2003 the INMA-INfancia y Medio Ambiente (Environment and Childhood) project, a Spanish national network of birth cohorts including more than 3500 participants, was set up with the aim to assess the health impacts of pre- and postnatal environmental exposures on children. The project has published more than 60 papers on maternal and environmental factors related to neuropsychological development in children, one of the main research interests within the project. With the present review, we evaluate the evidence provided by the INMA project on this topic and discuss how the data can contribute to cover the challenges that children's environmental health research will face in the coming years. RESULTS: The INMA project has contributed to provide increasing evidence of the association between prenatal exposure to persistent organic pollutants (POPs) and child neuropsychological development, but it has also shown, using innovative methodologies, that postnatal exposure to these compounds does not play a role in this association. The project has also contributed to show the detrimental influence of certain air pollutants on child neuropsychological development, as well as how a balanced maternal fish intake can protect from the potential adverse effects of prenatal exposure to mercury. Also, the project has contributed to the understanding of impacts of nutritional factors including supplement intake and vitamin D levels during pregnancy and the role of breastfeeding on the neuropsychological benefits. CONCLUSIONS: INMA findings underscore the importance of continued research on the delineation of the sensitive windows of exposure both during pregnancy and postnatally and on the combined effects of environmental exposures, denoted the exposome. In terms of health policy, INMA findings have important implications for the development of public health policies to advance the health and development of children. CI - Copyright (c) 2017 Elsevier GmbH. All rights reserved. FAU - Gascon, Mireia AU - Gascon M AD - ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: mireia.gascon@isglobal.org. FAU - Guxens, Monica AU - Guxens M AD - ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands. FAU - Vrijheid, Martine AU - Vrijheid M AD - ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain. FAU - Torrent, Maties AU - Torrent M AD - Area de Salut de Menorca, IB-SALUT, Menorca, Spain. FAU - Ibarluzea, Jesus AU - Ibarluzea J AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Subdireccion de Salud Publica de Gipuzkoa, The Basque Government's Health Department, San Sebastian, Spain; Faculty of Psychology, University of the Basque Country UPV/EHU, Donostia, Spain; BIODONOSTIA, Health Research Institute, San Sebastian, Basque Country, Spain. FAU - Fano, Eduardo AU - Fano E AD - Faculty of Psychology, University of the Basque Country UPV/EHU, Donostia, Spain; BIODONOSTIA, Health Research Institute, San Sebastian, Basque Country, Spain. FAU - Llop, Sabrina AU - Llop S AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de Valencia, Valencia, Spain. FAU - Ballester, Ferran AU - Ballester F AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de Valencia, Valencia, Spain. FAU - Fernandez, Mariana F AU - Fernandez MF AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; University of Granada, Complejo Hospitalario Universitario, Instituto de Investigacion Biosanitaria (ibs.GRANADA), Granada, Spain. FAU - Tardon, Adonina AU - Tardon A AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Area de Medicina Preventiva y Salud Publica, Departamento de Medicina, Universidad de Oviedo, Asturias, Spain. FAU - Fernandez-Somoano, Ana AU - Fernandez-Somoano A AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Area de Medicina Preventiva y Salud Publica, Departamento de Medicina, Universidad de Oviedo, Asturias, Spain. FAU - Sunyer, Jordi AU - Sunyer J AD - ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Catalonia, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20170228 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Environmental Pollutants) SB - IM MH - Animals MH - Brain/drug effects MH - Child MH - Child Development/*drug effects MH - Environmental Exposure MH - Environmental Pollutants/*toxicity MH - Humans MH - Neuropsychological Tests MH - Neuropsychology MH - Research OTO - NOTNLM OT - Environmental epidemiology OT - INMA project OT - Neuropsychological development OT - Pollutants OT - Postnatal OT - Prenatal EDAT- 2017/03/16 06:00 MHDA- 2017/11/29 06:00 CRDT- 2017/03/15 06:00 PHST- 2016/12/29 00:00 [received] PHST- 2017/02/27 00:00 [revised] PHST- 2017/02/27 00:00 [accepted] PHST- 2017/03/16 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] PHST- 2017/03/15 06:00 [entrez] AID - S1438-4639(16)30635-6 [pii] AID - 10.1016/j.ijheh.2017.02.008 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2017 Jun;220(4):647-658. doi: 10.1016/j.ijheh.2017.02.008. Epub 2017 Feb 28.