PMID- 28292012
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20180226
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 89
DP  - 2017 May
TI  - Up regulation of IL-6 is involved in di (2-ethylhexyl) phthalate (DEHP) induced 
      migration and invasion of non small cell lung cancer (NSCLC) cells.
PG  - 1037-1044
LID - S0753-3322(16)33005-0 [pii]
LID - 10.1016/j.biopha.2017.02.107 [doi]
AB  - Di (2-ethylhexyl) phthalate (DEHP), which is widely used in polyvinyl chloride 
      materials, can be easily accumulated into human body. Lung cancer cells can be 
      directly exposed to DEHP via inhalation, however, the effects and related 
      mechanisms of DEHP on the progression of non small cell lung cancer (NSCLC) were 
      not illustrated. Our present study revealed that DEHP less than 10(-4)M had no 
      significant effect on the proliferation of A549 or H1299 cells, while nanomolar 
      DEHP can trigger the migration and invasion of NSCLC cells. DEHP treatment also 
      increased the expression of interleukin-6 (IL-6) and IL-8. Silencing of IL-6, 
      while not IL-8, can attenuate DEHP induced migration and invasion of NSCLC cells. 
      This was confirmed by result that neutralization antibody of IL-6, while not 
      anti-IL-8, attenuated DEHP induced invasion of A549 cells. The inhibitor of 
      NF-kappaB, while not ERK1/2 or Akt, abolished DEHP induced up regulation of IL-6 and 
      invasion of NSCLC cells. DEHP treatment can increase the phosphorylation, nuclear 
      localization, and transcriptional activities of p65, one of the major parts of 
      NF-kappaB complex. Collectively, our study revealed that DEHP can stimulate NSCLC 
      migration and invasion via NF-kappaB mediated up regulation of IL-6.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Wang, Yingyi
AU  - Wang Y
AD  - Oncology Department of Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences, Dongcheng District, Beijing, 100730, PR China.
FAU - Zhao, Ming
AU  - Zhao M
AD  - Thoracic Surgery Department of China PLA General Hospital, No.28 Fuxing Road, 
      Haidian District, Beijing, 100853, PR China.
FAU - Liu, Jieying
AU  - Liu J
AD  - Oncology Department of Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences, Dongcheng District, Beijing, 100730, PR China.
FAU - Ni, Jianjiao
AU  - Ni J
AD  - Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng 
      District, Beijing, 100005, PR China.
FAU - Jiao, Yuchen
AU  - Jiao Y
AD  - Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular 
      Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences 
      & Peking Union Medical College, Chaoyang District, Beijing, 100021, PR China.
FAU - Bai, Chunmei
AU  - Bai C
AD  - Oncology Department of Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences, Dongcheng District, Beijing, 100730, PR China. Electronic 
      address: chunmeibai@126.com.
LA  - eng
PT  - Journal Article
DEP - 20170310
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (NF-kappa B)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement/*drug effects
MH  - Diethylhexyl Phthalate/*pharmacology
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Interleukin-6/genetics/*metabolism
MH  - Interleukin-8/genetics/metabolism
MH  - NF-kappa B
MH  - Neoplasm Invasiveness/*physiopathology
MH  - Up-Regulation/*drug effects
OTO - NOTNLM
OT  - DEHP
OT  - IL-6
OT  - Invasion
OT  - NF-kappaB
OT  - NSCLC
EDAT- 2017/03/16 06:00
MHDA- 2018/02/27 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/12/31 00:00 [received]
PHST- 2017/02/18 00:00 [revised]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - S0753-3322(16)33005-0 [pii]
AID - 10.1016/j.biopha.2017.02.107 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 May;89:1037-1044. doi: 10.1016/j.biopha.2017.02.107. 
      Epub 2017 Mar 10.