PMID- 28292084
OWN - NLM
STAT- MEDLINE
DCOM- 20170404
LR  - 20240324
IS  - 1937-8688 (Electronic)
VI  - 25
DP  - 2016
TI  - [Synchronous bilateral breast cancer: experiences in the Mohammed VI Cancer 
      Treatment Center, CHU Ibn Rochd, Casablanca].
PG  - 121
LID - 10.11604/pamj.2016.25.121.9967 [doi]
LID - 121
AB  - Synchronous bilateral breast cancers (SBBC) are characterized by extensive 
      clinical and morphological heterogeneity, with an frequency between 1.5 and 3.2%. 
      Women treated for unilateral breast cancer are at higher risk of developing 
      contralateral breast cancer. Screening and advances in breast imaging have 
      improved detection rates of SBBC. Our study aims to analyze the epidemiological, 
      clinical, histological and therapeutic features of bilateral breast cancer. We 
      conducted a cross-sectional study of patients with breast cancer treated at the 
      Mohammed VI Center over a two year period. Statistical analysis of the results 
      was performed using R. software. 31 patients had SBBC, representing 2.4% of 
      breast cancer cases in our Center. The average age was 47.8 +/- 8.4 years, 22.6% of 
      patients used oral contraceptives. A family history of breast cancer was observed 
      in 22.6% of cases. The most common histological type was invasive ductal 
      carcinoma (58.1%), SBR grade II and III were common (38.7%). Hormone receptors 
      were positive for progesterone (38.7%) and for estrogen (41.9%). HER2 was 
      overexpressed in 20.0% of cases. 29.0% of patients received hormonal therapy and 
      3.2% targeted therapies. Our study showed that bilateral breast cancer represents 
      a small percentage of all breast cancers but have specific clinical features that 
      help to differentiate it from unilateral breast cancer.
FAU - Khalil, Ahmadaye Ibrahim
AU  - Khalil AI
AD  - Laboratoire de Physiopathologie et Genetique Moleculaire, Faculte des Sciences 
      Ben M'Sik, Universite Hassan II, Casablanca, Maroc.
FAU - Bendahhou, Karima
AU  - Bendahhou K
AD  - Registre des Cancers de la Region du Grand Casablanca, Maroc.
FAU - Mestaghanmi, Houriya
AU  - Mestaghanmi H
AD  - Laboratoire de Physiopathologie et Genetique Moleculaire, Faculte des Sciences 
      Ben M'Sik, Universite Hassan II, Casablanca, Maroc.
FAU - Saile, Rachid
AU  - Saile R
AD  - Laboratoire de Biologie et Sante, Unite de Recherche Associee au CNRST-URAC 34, 
      Faculte des Sciences Ben M'Sik, Universite Hassan II, Casablanca, Maroc.
FAU - Benider, Abdellatif
AU  - Benider A
AD  - Centre Mohammed VI pour le Traitement des Cancers, CHU Ibn Rochd Casablanca, 
      Maroc.
LA  - fre
PT  - Journal Article
TT  - Cancer du sein bilateral synchrone: experiences du centre Mohammed VI pour le 
      traitement des cancers CHU Ibn Rochd Casablanca.
DEP - 20161027
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Contraceptives, Oral)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*pathology/therapy
MH  - Carcinoma, Ductal, Breast/epidemiology/*pathology/therapy
MH  - Contraceptives, Oral/administration & dosage
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Morocco
MH  - Neoplasms, Multiple Primary/*pathology/therapy
MH  - Receptors, Estrogen/metabolism
MH  - Receptors, Progesterone/metabolism
MH  - Retrospective Studies
PMC - PMC5325485
OTO - NOTNLM
OT  - Bilateral breast cancer
OT  - clinical
OT  - epidemiology
OT  - histology
OT  - therapeutic
COIS- Les auteurs ne declarent aucun conflit d'interet.
EDAT- 2017/03/16 06:00
MHDA- 2017/04/05 06:00
PMCR- 2016/10/27
CRDT- 2017/03/16 06:00
PHST- 2016/06/04 00:00 [received]
PHST- 2016/09/22 00:00 [accepted]
PHST- 2017/03/16 06:00 [entrez]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/04/05 06:00 [medline]
PHST- 2016/10/27 00:00 [pmc-release]
AID - PAMJ-25-121 [pii]
AID - 10.11604/pamj.2016.25.121.9967 [doi]
PST - epublish
SO  - Pan Afr Med J. 2016 Oct 27;25:121. doi: 10.11604/pamj.2016.25.121.9967. 
      eCollection 2016.