PMID- 28292830
OWN - NLM
STAT- MEDLINE
DCOM- 20170419
LR  - 20220330
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 37
IP  - 15
DP  - 2017 Apr 12
TI  - Adult Hippocampal Neurogenesis along the Dorsoventral Axis Contributes 
      Differentially to Environmental Enrichment Combined with Voluntary Exercise in 
      Alleviating Chronic Inflammatory Pain in Mice.
PG  - 4145-4157
LID - 10.1523/JNEUROSCI.3333-16.2017 [doi]
AB  - Cognitive behavioral therapy, such as environmental enrichment combined with 
      voluntary exercise (EE-VEx), is under active investigation as an adjunct to 
      pharmaceutical treatment for chronic pain. However, the effectiveness and 
      underlying mechanisms of EE-VEx remain unclear. In mice with intraplantar 
      injection of complete Freund's adjuvant, our results revealed that EE-VEx 
      alleviated perceptual, affective, and cognitive dimensions of chronic 
      inflammatory pain. These effects of EE-VEx on chronic pain were contingent on the 
      occurrence of adult neurogenesis in the dentate gyrus in a functionally 
      dissociated manner along the dorsoventral axis: neurogenesis in the ventral 
      dentate gyrus participated in alleviating perceptual and affective components of 
      chronic pain by EE-VEx, whereas neurogenesis in the dorsal dentate gyrus was 
      involved in EE-VEx's cognitive-enhancing effects. Chronic inflammatory pain was 
      accompanied by decreased levels of brain-derived neurotrophic factor (BDNF) in 
      the dentate gyrus, which were reversed by EE-VEx. Overexpression of BDNF in the 
      dentate gyrus mimicked the effects of EE-VEx. Our results demonstrate distinct 
      contribution of adult hippocampal neurogenesis along the dorsoventral axis to 
      EE-VEx's beneficial effects on different dimensions of chronic pain.SIGNIFICANCE 
      STATEMENT Environmental enrichment combined with voluntary exercise (EE-VEx) is 
      under active investigation as an adjunct to pharmaceutical treatment for chronic 
      pain, but its effectiveness and underlying mechanisms remain unclear. In a mouse 
      model of inflammatory pain, the present study demonstrates that the beneficial 
      effects of EE-VEx on chronic pain depend on adult neurogenesis with a 
      dorsoventral dissociation along the hippocampal axis. Adult neurogenesis in the 
      ventral dentate gyrus participates in alleviating perceptual and affective 
      components of chronic pain by EE-VEx, whereas that in the dorsal pole is involved 
      in EE-VEx's cognitive-enhancing effects in chronic pain.
CI  - Copyright (c) 2017 the authors 0270-6474/17/374145-13$15.00/0.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Jiang, Ying-Ying
AU  - Jiang YY
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Xu, Ling-Chi
AU  - Xu LC
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Ma, Long-Yu
AU  - Ma LY
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Liu, Feng-Yu
AU  - Liu FY
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Cui, Shuang
AU  - Cui S
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Cai, Jie
AU  - Cai J
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Liao, Fei-Fei
AU  - Liao FF
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and.
FAU - Wan, You
AU  - Wan Y
AUID- ORCID: 0000-0001-6110-7192
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and ywan@hsc.pku.edu.cn mingyi@bjmu.edu.cn.
AD  - Key Laboratory for Neuroscience, Ministry of Education/National Health and Family 
      Planning Commission, Peking University, Beijing 100191, P.R. China.
FAU - Yi, Ming
AU  - Yi M
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, and ywan@hsc.pku.edu.cn mingyi@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170314
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
EIN - J Neurosci. 2021 Feb 17;41(7):1618-1620. PMID: 33526477
MH  - Age Factors
MH  - Animals
MH  - Chronic Pain/pathology/*therapy
MH  - *Environment
MH  - Hippocampus/*cytology/*physiology
MH  - Inflammation/pathology/therapy
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neurogenesis/*physiology
MH  - Physical Conditioning, Animal/methods/*physiology
PMC - PMC6596585
OTO - NOTNLM
OT  - adult neurogenesis
OT  - anxiety
OT  - brain-derived neurotrophic factor
OT  - chronic inflammatory pain
OT  - environmental enrichment
OT  - hippocampus
EDAT- 2017/03/16 06:00
MHDA- 2017/04/20 06:00
PMCR- 2017/10/12
CRDT- 2017/03/16 06:00
PHST- 2016/10/27 00:00 [received]
PHST- 2017/02/27 00:00 [revised]
PHST- 2017/03/02 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/04/20 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
PHST- 2017/10/12 00:00 [pmc-release]
AID - JNEUROSCI.3333-16.2017 [pii]
AID - 3333-16 [pii]
AID - 10.1523/JNEUROSCI.3333-16.2017 [doi]
PST - ppublish
SO  - J Neurosci. 2017 Apr 12;37(15):4145-4157. doi: 10.1523/JNEUROSCI.3333-16.2017. 
      Epub 2017 Mar 14.