PMID- 28293263
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder 
      through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous 
      Hypertensive Rats.
PG  - 2695903
LID - 10.1155/2017/2695903 [doi]
LID - 2695903
AB  - The disturbed dopamine availability and brain-derived neurotrophic factor (BDNF) 
      expression are due in part to be associated with attention deficit hyperactivity 
      disorder (ADHD). In this study, we investigated the therapeutical effect of 
      saikosaponin a (SSa) isolated from Bupleurum Chinese DC, against spontaneously 
      hypertensive rat (SHR) model of ADHD. Methylphenidate and SSa were orally 
      administered for 3 weeks. Activity was assessed by open-field test and Morris 
      water maze test. Dopamine (DA) and BDNF were determined in specific brain 
      regions. The mRNA or protein expression of tyrosine hydroxylase (TH), dopamine 
      transporter (DAT), and vesicles monoamine transporter (VMAT) was also studied. 
      Both MPH and SSa reduced hyperactivity and improved the spatial learning memory 
      deficit in SHRs. An increased DA concentration in the prefrontal cortex (PFC) and 
      striatum was also observed after treating with the SSa. The increased DA 
      concentration may partially be attributed to the decreased mRNA and protein 
      expression of DAT in PFC while SSa exhibited no significant effects on the mRNA 
      expression of TH and VMAT in PFC of SHRs. In addition, BDNF expression in SHRs 
      was also increased after treating with SSa or MPH. The obtained result suggested 
      that SSa may be a potential drug for treating ADHD.
FAU - Jichao, Sun
AU  - Jichao S
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Xinmin, Han
AU  - Xinmin H
AUID- ORCID: 0000-0001-8935-8997
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Xianguo, Ren
AU  - Xianguo R
AD  - Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu 210002, 
      China.
FAU - Dongqi, Yin
AU  - Dongqi Y
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Rongyi, Zhou
AU  - Rongyi Z
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Shuang, Lei
AU  - Shuang L
AD  - Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Yue, You
AU  - Yue Y
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Yuchen, Song
AU  - Yuchen S
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
FAU - Jingnan, Ying
AU  - Jingnan Y
AD  - The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 
      Jiangsu 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease, 
      Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 
      210023, China.
LA  - eng
PT  - Journal Article
DEP - 20170215
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5331296
COIS- The authors declare no conflict of interests.
EDAT- 2017/03/16 06:00
MHDA- 2017/03/16 06:01
PMCR- 2017/02/15
CRDT- 2017/03/16 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2016/12/18 00:00 [accepted]
PHST- 2017/03/16 06:00 [entrez]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/03/16 06:01 [medline]
PHST- 2017/02/15 00:00 [pmc-release]
AID - 10.1155/2017/2695903 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:2695903. doi: 10.1155/2017/2695903. 
      Epub 2017 Feb 15.