PMID- 28293819
OWN - NLM
STAT- MEDLINE
DCOM- 20170707
LR  - 20181113
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 106
IP  - 1
DP  - 2017 Jul
TI  - Characteristics features and factors influencing early death in Acute 
      promyelocytic leukemia; Experience from United Arab Emirates (UAE).
PG  - 90-98
LID - 10.1007/s12185-017-2211-7 [doi]
AB  - Although acute promyelocytic leukemia (APL) is a curable hematologic malignancy, 
      early death (ED) remains a significant cause of treatment failure especially in 
      developing countries. In a retrospective data analysis of 67 adult APL patients 
      diagnosed in United Arab Emirates we report an ED rate of 11.9% which is 
      comparable to that reported from more developed countries. We identified the 
      following parameters at presentation as significant predictor of increased ED: 
      Age >40 years (P = 0.015), fever (P = 0.030), WBC count >20 x 10(9)/L 
      (P = 0.010), the breakpoints other than bcr1 (P = 0.043) and fibrinogen level 
      <1.5 g/L (P = 0.025). Delay in ATRA administration beyond 24 h from admission and 
      fibrinogen <150 mg/dL were also significant predictors of ED, but only among 
      high-risk patients (P = 0.035 and P = 0.033, respectively). WBC count 
      >10 x 10(9)/L and expression of HLA-DR (P = 0.018) or CD2 (P = 0.017) were 
      significant predictors for differentiation syndrome (DS) which was found to be a 
      predictor of ED (P = 0.002). Reducing the APL related ED rate in centers with 
      limited resources is feasible provided early initiation of ATRA administration 
      and early correction of coagulopathy in high-risk patients in addition to prompt 
      treatment of DS. To our knowledge this is the first report from the Arabian Gulf 
      describing ED in APL.
FAU - Hassan, Inaam Bashir
AU  - Hassan IB
AD  - Department of Internal Medicine, College of Medicine and Health Sciences, United 
      Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. 
      inaambh@uaeu.ac.ae.
AD  - Department of Oncology Tawam Hospital, AlAin, United Arab Emirates. 
      inaambh@uaeu.ac.ae.
FAU - Zaabi, Mariam R Al
AU  - Zaabi MRA
AD  - Department of Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United 
      Arab Emirates.
FAU - Alam, Arif
AU  - Alam A
AD  - Department of Oncology Tawam Hospital, AlAin, United Arab Emirates.
FAU - Hashim, Mohammed Jawad
AU  - Hashim MJ
AD  - Department of Family Medicine, College of Medicine and Health Sciences, United 
      Arab Emirates University, Abu Dhabi, United Arab Emirates.
FAU - Tallman, Martin S
AU  - Tallman MS
AD  - Memorial Sloan Kettering Cancer Center, Rockville Centre, New York, USA.
FAU - Kristensen, Jorgen
AU  - Kristensen J
AD  - Department of Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United 
      Arab Emirates.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Blood Coagulation
MH  - Cytogenetic Analysis
MH  - Female
MH  - Hematologic Tests
MH  - Humans
MH  - Leukemia, Promyelocytic, Acute/*diagnosis/drug therapy/*mortality
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - *Phenotype
MH  - Prognosis
MH  - Time-to-Treatment
MH  - Treatment Outcome
MH  - United Arab Emirates
MH  - Young Adult
OTO - NOTNLM
OT  - Acute promyelocytic leukemia
OT  - Early death
OT  - United Arab Emirates
EDAT- 2017/03/16 06:00
MHDA- 2017/07/08 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/12/08 00:00 [received]
PHST- 2017/03/09 00:00 [accepted]
PHST- 2017/03/09 00:00 [revised]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/07/08 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 10.1007/s12185-017-2211-7 [pii]
AID - 10.1007/s12185-017-2211-7 [doi]
PST - ppublish
SO  - Int J Hematol. 2017 Jul;106(1):90-98. doi: 10.1007/s12185-017-2211-7. Epub 2017 
      Mar 14.