PMID- 28293972
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20220318
IS  - 1502-7732 (Electronic)
IS  - 0300-9742 (Linking)
VI  - 46
IP  - 6
DP  - 2017 Nov
TI  - A comparison of patients' and physicians' assessments of disease activity using 
      the Swedish version of the Systemic Lupus Activity Questionnaire.
PG  - 474-483
LID - 10.1080/03009742.2016.1276959 [doi]
AB  - OBJECTIVES: We compared patients' assessments of systemic lupus erythematosus 
      (SLE) disease activity by a Swedish version of the Systemic Lupus Activity 
      Questionnaire (SLAQ) with physicians' assessments by the Systemic Lupus Activity 
      Measure (SLAM) and Systemic Lupus Erythematosus Disease Activity Index 2000 
      (SLEDAI-2K). We also explored the performance of the SLAQ in patients with short 
      (< 1 year) versus long (>/= 1 year) disease duration. METHOD: Patients filled out 
      the SLAQ before physicians' assessments. Correlations between SLAQ total, 
      subscales (Symptom score, Flares, Patients global) and SLAM and SLEDAI-2K, as 
      well as between the corresponding items in SLAQ and SLAM, were evaluated using 
      Spearman's rho. Comparisons between patients with different disease durations were 
      performed with Mann-Whitney U or chi-squared tests. RESULTS: We included 203 
      patients (79% women), with a median age of 45 years [interquartile range (IQR) 
      33-57 years] and disease duration of 5 years (IQR 0-14 years). Correlations 
      between physicians' SLAM without laboratory items (SLAM-nolab) and patients' 
      assessments were: SLAQ total, rho = 0.685, Symptom score, rho = 0.651, Flares, 
      rho = 0.547, and Patients global, rho = 0.600. Of the symptom items, fatigue 
      (rho = 0.640), seizures (rho = 0.635), and headache (rho = 0.604) correlated most 
      closely. Neurology/stroke syndrome, skin, and lymphadenopathy correlated less 
      well (rho < 0.24). Patients' and physicians' assessments were notably more 
      discordant for patients with short disease durations. CONCLUSION: We confirm that 
      the SLAQ can be used to monitor disease activity. However, the discrepancy 
      between patients' and physicians' assessments was greater for patients with short 
      versus long disease duration. We encourage further use of the SLAQ, but would 
      like to develop a shorter version which would be valuable in modern, partly 
      web-based, clinical care.
FAU - Pettersson, S
AU  - Pettersson S
AD  - a Rheumatology Clinic , Karolinska University Hospital , Stockholm , Sweden.
AD  - b Division of Physiotherapy, Department of Neurobiology, Care Sciences and 
      Society , Karolinska Institutet , Stockholm , Sweden.
FAU - Svenungsson, E
AU  - Svenungsson E
AD  - a Rheumatology Clinic , Karolinska University Hospital , Stockholm , Sweden.
AD  - c Rheumatology Unit, Department of Medicine , Karolinska Institutet, Solna , 
      Stockholm , Sweden.
FAU - Gustafsson, J
AU  - Gustafsson J
AD  - a Rheumatology Clinic , Karolinska University Hospital , Stockholm , Sweden.
AD  - c Rheumatology Unit, Department of Medicine , Karolinska Institutet, Solna , 
      Stockholm , Sweden.
FAU - Moller, S
AU  - Moller S
AD  - a Rheumatology Clinic , Karolinska University Hospital , Stockholm , Sweden.
FAU - Gunnarsson, I
AU  - Gunnarsson I
AD  - a Rheumatology Clinic , Karolinska University Hospital , Stockholm , Sweden.
AD  - c Rheumatology Unit, Department of Medicine , Karolinska Institutet, Solna , 
      Stockholm , Sweden.
FAU - Welin Henriksson, E
AU  - Welin Henriksson E
AD  - a Rheumatology Clinic , Karolinska University Hospital , Stockholm , Sweden.
AD  - d Division of Nursing, Department of Neurobiology Care Sciences and Society , 
      Karolinska Institutet , Stockholm , Sweden.
AD  - e Division of Nursing Science, Department of Medical and Health Sciences , 
      Linkoping University , Linkoping , Sweden.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170315
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
SB  - IM
MH  - Adult
MH  - Disease Progression
MH  - Fatigue/etiology/*physiopathology
MH  - Female
MH  - Headache/etiology/*physiopathology
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/etiology/physiopathology
MH  - Lupus Erythematosus, Systemic/complications/*physiopathology
MH  - Lupus Vasculitis, Central Nervous System/complications/physiopathology
MH  - Lymphadenopathy/etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Patient Reported Outcome Measures
MH  - Seizures/etiology/*physiopathology
MH  - Severity of Illness Index
MH  - Stroke/etiology/physiopathology
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2017/03/16 06:00
MHDA- 2017/11/08 06:00
CRDT- 2017/03/16 06:00
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 10.1080/03009742.2016.1276959 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2017 Nov;46(6):474-483. doi: 10.1080/03009742.2016.1276959. 
      Epub 2017 Mar 15.