PMID- 28294061
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20221207
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 14
IP  - 2
DP  - 2017
TI  - The Association of MME microRNA Binding Site Polymorphism with the Risk of Late 
      Onset Alzheimer's Disease in Northern Han Chinese.
PG  - 90-95
LID - 10.2174/1567202614666170313110301 [doi]
AB  - BACKGROUND: Although beta-amyloid (Abeta) degradation has been normally implicated in 
      the pathogenesis of late-onset Alzheimer's disease (LOAD) through cellular 
      biological studies, the genetic studies linking Abeta degradation and LOAD are still 
      scarce. Neprilysin (NEP), one of the most crucial Abeta-degrading enzymes in AD, is 
      the metalloendopeptidase which particularly participates in the monomeric Abeta 
      species degradation. MicroRNAs (miRNAs) exert post-transcriptional dysregulation 
      and their target sequence on the 3' untranslated regions (3'UTR) may be regulated 
      by single nucleotide polymorphisms (SNPs). OBJECTIVE: To investigate the 
      potential risk of common locus within NEP gene (MME) with LOAD in Northern Han 
      Chinese population. METHOD: We screened a locus (rs6665) in 3' UTR of NEP gene 
      (MME) which sequence was specially regulated by miRNA-187, and further 
      investigated its possible association with LOAD onset in a large case-control 
      study (984 LOAD patients and 1354 healthy controls) in Northern Han Chinese. 
      RESULTS: The distribution of rs6665 genotype (P=0.003) and allele A/C (P=0.001) 
      showed significant difference between LOAD and controls (Odds Ratio (OR) =1.255, 
      95% Confidence Interval (CI) =1.102-1.429). After adjusting for age, gender and 
      Apolipoprotein (ApoE) epsilon4 status, the minor C allele of rs6665 showed significant 
      association with LOAD in all three genotypic models (Dominant: P=0.003, OR=1.291, 
      95%CI=1.092-1.526; Recessive: P=0.030, OR =1.425, 95%CI =1.035- 1.961; Additive: 
      P=0.001, OR=1.249,95%CI=1.093-1.427). After stratifying by ApoE epsilon4 status, rs6665 
      polymorphism was found to elevate the LOAD risk in ApoE epsilon4 carriers (P=0.002, 
      OR=1.846, 95%CI=1.264-2.697). CONCLUSION: Our study firstly confirmed the 
      association of MME miRNA binding site polymorphism with the risk of LOAD. 
      However, the association results warrant further validation.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Liu, Chun-Xia
AU  - Liu CX
AD  - Department of Neurology, Heze Medical College, Heze, Shandong, China.
FAU - Tan, Lin
AU  - Tan L
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Sun, Fu-Rong
AU  - Sun FR
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Miao, Dan
AU  - Miao D
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Tan, Meng-Shan
AU  - Tan MS
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Wan, Yu
AU  - Wan Y
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Tan, Chen-Chen
AU  - Tan CC
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Yu, Jin-Tai
AU  - Yu JT
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Tan, Lan
AU  - Tan L
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, No.5 Donghai Middle Road, Qingdao, Shandong Province 266071, China.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Apolipoproteins E)
RN  - 0 (MicroRNAs)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/ethnology/*genetics
MH  - Apolipoproteins E/genetics
MH  - Asian People/ethnology/genetics
MH  - Binding Sites/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mental Status Schedule
MH  - MicroRNAs/*genetics
MH  - Neprilysin/*genetics/metabolism
MH  - Polymorphism, Single Nucleotide/*genetics
OTO - NOTNLM
OT  - MME
OT  - Neprilysin
OT  - late onset alzheimer's disease
OT  - polymorphism
OT  - rs6665
EDAT- 2017/03/16 06:00
MHDA- 2018/03/23 06:00
CRDT- 2017/03/16 06:00
PHST- 2017/02/06 00:00 [received]
PHST- 2017/02/14 00:00 [revised]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - CNR-EPUB-82244 [pii]
AID - 10.2174/1567202614666170313110301 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2017;14(2):90-95. doi: 10.2174/1567202614666170313110301.