PMID- 28294457
OWN - NLM
STAT- MEDLINE
DCOM- 20180301
LR  - 20240313
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 38
IP  - 6
DP  - 2017 Jun
TI  - Structural and functional brain network correlates of depressive symptoms in 
      premanifest Huntington's disease.
PG  - 2819-2829
LID - 10.1002/hbm.23527 [doi]
AB  - Depression is common in premanifest Huntington's disease (preHD) and results in 
      significant morbidity. We sought to examine how variations in structural and 
      functional brain networks relate to depressive symptoms in premanifest HD and 
      healthy controls. Brain networks were constructed using diffusion tractography 
      (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) 
      data. A sub-network associated with depression was identified in a data-driven 
      fashion and network-based statistics was used to investigate which specific 
      connections correlated with depression scores. A replication analysis was then 
      performed using data from a separate study. Correlations between depressive 
      symptoms with increased functional connectivity and decreased structural 
      connectivity were seen for connections in the default mode network (DMN) and 
      basal ganglia in preHD. This study reveals specific connections in the DMN and 
      basal ganglia that are associated with depressive symptoms in preHD. Hum Brain 
      Mapp 38:2819-2829, 2017. (c) 2017 The Authors Human Brain Mapping Published by 
      Wiley Periodicals, Inc.
CI  - (c) 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
FAU - McColgan, Peter
AU  - McColgan P
AD  - Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 
      3BG, United Kingdom.
FAU - Razi, Adeel
AU  - Razi A
AD  - Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 
      3BG, United Kingdom.
AD  - Department of Electronic Engineering, NED University of Engineering and 
      Technology, Karachi, Pakistan.
FAU - Gregory, Sarah
AU  - Gregory S
AD  - Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 
      3BG, United Kingdom.
FAU - Seunarine, Kiran K
AU  - Seunarine KK
AD  - Developmental Imaging and Biophysics Section, UCL Institute of Child Health, 
      London, WC1N 1EH, United Kingdom.
FAU - Durr, Alexandra
AU  - Durr A
AD  - APHP Department of Genetics, Groupe Hospitalier Pitie-Salpetriere, and Institut 
      du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, Sorbonne Universites - 
      UPMC Universite Paris VI UMR_S1127, Paris, France.
FAU - A C Roos, Raymund
AU  - A C Roos R
AD  - Department of Neurology, Leiden University Medical Centre, 2300RC Leiden, The 
      Netherlands.
FAU - Leavitt, Blair R
AU  - Leavitt BR
AD  - Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, 
      University of British Columbia, 950 West 28th Avenue, Vancouver, British 
      Columbia, V5Z 4H4, Canada.
FAU - Scahill, Rachael I
AU  - Scahill RI
AD  - Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 
      3BG, United Kingdom.
FAU - Clark, Chris A
AU  - Clark CA
AD  - Developmental Imaging and Biophysics Section, UCL Institute of Child Health, 
      London, WC1N 1EH, United Kingdom.
FAU - Langbehn, Doug R
AU  - Langbehn DR
AD  - Department of Biostatistics, University of Iowa, Iowa City, Iowa.
FAU - Rees, Geraint
AU  - Rees G
AD  - Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 
      3BG, United Kingdom.
FAU - Tabrizi, Sarah J
AU  - Tabrizi SJ
AD  - Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 
      3BG, United Kingdom.
AD  - National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, 
      United Kingdom.
CN  - Track On-HD Investigators
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 200181/Z/15/Z/WT_/Wellcome Trust/United Kingdom
GR  - MR/L012936/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170315
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Apathy
MH  - Brain/*diagnostic imaging/*physiopathology
MH  - *Brain Mapping
MH  - Cohort Studies
MH  - Depressive Disorder/etiology/*pathology
MH  - Female
MH  - Humans
MH  - Huntington Disease/complications
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/*diagnostic imaging/pathology/*physiopathology
MH  - Oxygen/blood
MH  - Psychiatric Status Rating Scales
PMC - PMC5434856
OTO - NOTNLM
OT  - Huntington's disease
OT  - brain network
OT  - depression
OT  - diffusion tractography
OT  - functional MRI
EDAT- 2017/03/16 06:00
MHDA- 2018/03/02 06:00
PMCR- 2017/03/15
CRDT- 2017/03/16 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2016/11/25 00:00 [revised]
PHST- 2016/12/15 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2018/03/02 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
PHST- 2017/03/15 00:00 [pmc-release]
AID - HBM23527 [pii]
AID - 10.1002/hbm.23527 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2017 Jun;38(6):2819-2829. doi: 10.1002/hbm.23527. Epub 2017 Mar 
      15.