PMID- 28294535
OWN - NLM
STAT- MEDLINE
DCOM- 20180801
LR  - 20180801
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Linking)
VI  - 16
IP  - 4
DP  - 2017 Dec
TI  - Comparative study of autologous fat vs hyaluronic acid in correction of the 
      nasolabial folds.
PG  - e1-e8
LID - 10.1111/jocd.12333 [doi]
AB  - OBJECTIVE: In the article, comparison of the hyaluronic acid (HA) and autologous 
      fat is conducted to evaluate the effectiveness and safety in correction of the 
      nasolabial folds (NLFs). METHODS: From November 2012 to December 2015, a 
      single-blinded, randomized study was conducted. Sixty-two patients were included 
      in the study, and 57 of them completed the whole procedure. The patients were 
      randomly allocated to receive the treatments of HA or fat in both NLFs. The 
      Wrinkle Severity Rating Scale (WSRS) and Global Aesthetic Improvement Scale 
      (GAIS) were used for assessment. Efficacy was assessed using two parameters: 
      evaluation of final improvement by blinded evaluator and patient-self using 
      photographs. The effectiveness endpoint was improvement of scores at 1, 3, 6, 9, 
      and 12 months from baseline. The adverse events (AEs) were recorded. RESULTS: In 
      the blinded evaluator scores for NLF in accordance with WSRS, there were no 
      significant differences between the two methods within 9 months. A statistically 
      significant difference between the lipoinjection and HA groups was found at 
      12-month follow-up period. Subjects' self-assessment was similar to the results 
      seen for the evaluator scores. The difference of AEs between the HA and fat group 
      was obvious in the early stage of recovery. In the later stage, the AEs of the HA 
      and fat group were similar. CONCLUSIONS: Both HA gel and autologous fat provide 
      augmentation of NLFs. The magnitude and duration of NLF correction appear to be 
      similarly effective and safe within a period.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Hu, Xiaogen
AU  - Hu X
AD  - Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
FAU - Xue, Zhiqiang
AU  - Xue Z
AD  - Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
FAU - Qi, Huijie
AU  - Qi H
AD  - Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
FAU - Chen, Bo
AU  - Chen B
AD  - Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170314
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
RN  - 0 (Dermal Fillers)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dermal Fillers/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Nasolabial Fold
MH  - Rhytidoplasty/adverse effects/*methods
MH  - Single-Blind Method
MH  - *Skin Aging
MH  - Subcutaneous Fat/*transplantation
MH  - Time Factors
MH  - Transplantation, Autologous/adverse effects
OTO - NOTNLM
OT  - clinical research
OT  - facial rejuvenation
OT  - fat injections
OT  - filler
EDAT- 2017/03/16 06:00
MHDA- 2018/08/02 06:00
CRDT- 2017/03/16 06:00
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2018/08/02 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 10.1111/jocd.12333 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2017 Dec;16(4):e1-e8. doi: 10.1111/jocd.12333. Epub 2017 Mar 
      14.