PMID- 28294743
OWN - NLM
STAT- MEDLINE
DCOM- 20180208
LR  - 20191113
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 56
IP  - 2
DP  - 2016 Feb
TI  - [The Study of Associations of Polymorphisms of Candidate Gene of Cardiovascular 
      Diseases With Reduction of Glomerular Filtration Rate in Patients With ST Segment 
      Elevation Myocardial Infarction].
PG  - 11-18
AB  - AIM: to study associations of polymorphic genetic variants of inflammatory 
      response, endothelial function, lipid metabolism, and blood coagulation with 
      impaired renal function in patients with ST elevation myocardial infarction 
      (STEMI). MATERIAL AND METHODS: We enrolled in the study 171 patients admitted to 
      the Kemerovo Cardiology Dispensary within 24 hours after onset of STEMI. All 
      patients underwent genotype identification of 25 polymorphic variants of 18 major 
      candidate genes for cardiovascular disease. Genotyping was performed with DNA 
      chip SINKAR-1 (Institute of Medical Genetics and LLC "Genomic Diagnosis"). 
      Glomerular filtration rate (GFR) was estimated using serum creatinine level 
      measured at admission. RESULTS: Comparison of allelic and genotype frequencies of 
      the studied polymorphisms revealed that angiotensin-converting enzyme (ACE) gene 
      rs4291 was associated with decreased GFR: odds ratio (OR) for carriers of rare TT 
      genotype was 2.31 [1.01-5.25], =0.043. Analysis of genotype combinations of ACE 
      rs4343 polymorphism and hepatic lipase gene (LIPC) rs1800588 showed that AA 
      genotype of rs4343 polymorphism in combination with CC genotype of rs1800588 
      polymorphism was associated with lowest risk of renal dysfunction, whereas GG and 
      AG genotypes of ACE rs4343 in combination with TT and CT genotypes of LIPC 
      rs1800588.
FAU - Zykov, M V
AU  - Zykov MV
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Makeeva, O A
AU  - Makeeva OA
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Golubenko, M V
AU  - Golubenko MV
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Kashtalap, V V
AU  - Kashtalap VV
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Kulish, E V
AU  - Kulish EV
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Bykova, I S
AU  - Bykova IS
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Kalaeva, V V
AU  - Kalaeva VV
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Karetnikova, V N
AU  - Karetnikova VN
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Barbarash, O L
AU  - Barbarash OL
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
FAU - Puzyrev, V P
AU  - Puzyrev VP
AD  - 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, 
      Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State 
      Medical Academy, Kemerovo, Russia.
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
SB  - IM
MH  - Alleles
MH  - Cardiovascular Diseases
MH  - Genotype
MH  - *Glomerular Filtration Rate/genetics
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Genetic
MH  - *ST Elevation Myocardial Infarction/genetics/physiopathology
EDAT- 2017/03/16 06:00
MHDA- 2018/02/09 06:00
CRDT- 2017/03/16 06:00
PHST- 2017/03/16 06:00 [entrez]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2018/02/09 06:00 [medline]
AID - 10.18565/cardio.2016.2.11-18 [doi]
PST - ppublish
SO  - Kardiologiia. 2016 Feb;56(2):11-18. doi: 10.18565/cardio.2016.2.11-18.