PMID- 28295397
OWN - NLM
STAT- MEDLINE
DCOM- 20170504
LR  - 20170504
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 57
IP  - 5
DP  - 2017 May
TI  - Red blood cell transfusions can induce proinflammatory cytokines in preterm 
      infants.
PG  - 1304-1310
LID - 10.1111/trf.14080 [doi]
AB  - BACKGROUND: The risk of developing red blood cell (RBC) transfusion-associated 
      necrotizing enterocolitis (TANEC) in preterm infants has recently been 
      emphasized. Our aim was to assess changes in cytokine serum levels after RBC 
      transfusions in a cohort of very preterm infants to evaluate their possible 
      proinflammatory effect. STUDY DESIGN AND METHODS: We carried out a prospective 
      observational study. One transfusion event was studied in infants less than 32 
      weeks' gestation and more than 7 days old (n = 20) admitted to a tertiary 
      neonatal intensive care unit. Interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis 
      factor-alpha, interferon-gamma (IFN-gamma), IL-17, monocyte chemoattractant protein-1 
      (MCP-1), interferon-gamma-induced protein 10 (IP-10), intracellular adhesion 
      molecule-1 (ICAM-1), and vascular cell adhesion molecule serum levels were 
      measured in enrolled patients within 120 minutes before (T(0) ) the RBC 
      transfusion and then within 120 minutes (T(1) ), 12 +/- 3 hours (T(2) ), 24 +/- 6 
      hours (T(3) ), and 48 +/- 6 hours (T(4) ) after the end of RBC transfusion. 
      RESULTS: Infants received 19.8 +/- 3.0 mL of RBCs at the mean age of 50 +/- 18 days. 
      Their hematocrit level increased from 24.1 +/- 1.2% to 39.4 +/- 2.9%. IL-1beta, IL-8, 
      IFN-gamma, IL-17, MCP-1, IP-10, and ICAM-1 increased significantly after RBC 
      transfusions. CONCLUSION: Proinflammatory cytokines are increased after RBC 
      transfusion. These findings may contribute to explaining the pathogenesis of 
      TANEC and suggest the opportunity of adopting wise transfusion guidelines that 
      would help to avoid detrimental risks of transfusion-related immunomodulation and 
      of undertransfusion.
CI  - (c) 2017 AABB.
FAU - Dani, Carlo
AU  - Dani C
AD  - Department of Neurosciences, Psychology, Drug Research and Child Health.
FAU - Poggi, Chiara
AU  - Poggi C
AD  - Division of Neonatology.
FAU - Gozzini, Elena
AU  - Gozzini E
AD  - Division of Neonatology.
FAU - Leonardi, Valentina
AU  - Leonardi V
AD  - Division of Neonatology.
FAU - Sereni, Alice
AU  - Sereni A
AD  - Department of Experimental and Clinical Medicine, University of 
      Florence-Atherothrombotic Diseases Centre, Careggi University Hospital of 
      Florence, Florence, Italy.
FAU - Abbate, Rosanna
AU  - Abbate R
AD  - Department of Experimental and Clinical Medicine, University of 
      Florence-Atherothrombotic Diseases Centre, Careggi University Hospital of 
      Florence, Florence, Italy.
FAU - Gori, Anna Maria
AU  - Gori AM
AD  - Department of Experimental and Clinical Medicine, University of 
      Florence-Atherothrombotic Diseases Centre, Careggi University Hospital of 
      Florence, Florence, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170311
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Cytokines/*blood/genetics
MH  - Enterocolitis, Necrotizing/etiology
MH  - Erythrocyte Transfusion/*adverse effects
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Immunomodulation
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Inflammation Mediators
MH  - Intensive Care Units, Neonatal
MH  - Male
MH  - Prospective Studies
MH  - Transcriptional Activation
EDAT- 2017/03/16 06:00
MHDA- 2017/05/05 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/08/18 00:00 [received]
PHST- 2016/11/28 00:00 [revised]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/05/05 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 10.1111/trf.14080 [doi]
PST - ppublish
SO  - Transfusion. 2017 May;57(5):1304-1310. doi: 10.1111/trf.14080. Epub 2017 Mar 11.