PMID- 28295950
OWN - NLM
STAT- MEDLINE
DCOM- 20171005
LR  - 20211204
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 32
IP  - 7
DP  - 2017 Jul
TI  - Sulforaphane attenuates di-N-butylphthalate-induced reproductive damage in 
      pubertal mice: Involvement of the Nrf2-antioxidant system.
PG  - 1908-1917
LID - 10.1002/tox.22413 [doi]
AB  - di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for 
      plastic coating and in the cosmetics industry. It has toxic effects on body 
      health, especially the male reproductive system. Here, we investigated the 
      effects of DBP on the male reproductive system of pubertal mice and explored the 
      protective role of sulforaphane (SFN). The results showed that DBP significantly 
      reduced the anogenital distance, testicular weight, sperm count and motility, and 
      plasma and testicular testosterone levels and significantly increased the 
      oxidative stress, sperm abnormalities, and testicular cell apoptosis. SFN 
      supplementation ameliorated these effects. After DBP stimulation, the 
      transcription factor nuclear factor erythroid-related factor 2 (Nrf2) was 
      adaptively increased together with its target genes, such as HO-1 and NQO1. 
      Upregulation of Nrf2 by SFN reduced the DBP-mediated intracellular oxidative 
      toxicity and also increased testosterone secretion and spermatogenesis, which 
      were decreased by DBP. These findings indicate that SFN can attenuate DBP-induced 
      reproductive damage in pubertal mice via Nrf2-associated pathways.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Jiang, Xu-Ping
AU  - Jiang XP
AD  - Department of Urology, Affiliated Yixing Hospital of Jiangsu University, Yixing, 
      214200, China.
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Tang, Jing-Yuan
AU  - Tang JY
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
AD  - Department of Urology, Wuxi Second People's Hospital, Nanjing Medical University, 
      Wuxi, 214002, China.
FAU - Xu, Zhen
AU  - Xu Z
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Han, Peng
AU  - Han P
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Qin, Zhi-Qiang
AU  - Qin ZQ
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Yang, Cheng-di
AU  - Yang CD
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Wang, Shang-Qian
AU  - Wang SQ
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Qin, Chao
AU  - Qin C
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
FAU - Xu, Yang
AU  - Xu Y
AD  - Department of Urology and Andrology, Drum Tower Hospital, Nanjing, 210008, China.
FAU - Shen, Bai-Xin
AU  - Shen BX
AD  - Department of Urology, Second Affiliated Hospital of Nanjing Medical University, 
      Nanjing, 210011, China.
FAU - Zhou, Wei-Min
AU  - Zhou WM
AD  - Department of Urology, Affiliated Yixing Hospital of Jiangsu University, Yixing, 
      214200, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Urology, State Key Laboratory of Reproductive Medicine, The First 
      Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
LA  - eng
PT  - Journal Article
DEP - 20170315
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Antioxidants)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Isothiocyanates)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Sulfoxides)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - GA49J4310U (sulforaphane)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Apoptosis/drug effects
MH  - Dibutyl Phthalate/*toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Isothiocyanates/*pharmacology
MH  - Male
MH  - Mice
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Oxidation-Reduction
MH  - Oxidative Stress/drug effects
MH  - Reproduction/*drug effects
MH  - Sperm Count
MH  - Sperm Motility/drug effects
MH  - Sulfoxides
MH  - Testis/cytology/drug effects
MH  - Up-Regulation
OTO - NOTNLM
OT  - Nrf2
OT  - di-N-butylphthalate
OT  - oxidative stress
OT  - sulforaphane
EDAT- 2017/03/16 06:00
MHDA- 2017/10/06 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/10/15 00:00 [received]
PHST- 2017/02/21 00:00 [revised]
PHST- 2017/02/21 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/10/06 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 10.1002/tox.22413 [doi]
PST - ppublish
SO  - Environ Toxicol. 2017 Jul;32(7):1908-1917. doi: 10.1002/tox.22413. Epub 2017 Mar 
      15.