PMID- 28296231
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20221207
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 89
IP  - 5
DP  - 2017 May
TI  - High-resolution HLA-A, -B and -DRB1 allele and haplotype frequencies in 7823 Han 
      marrow donors of Liaoning province, China.
PG  - 293-300
LID - 10.1111/tan.13006 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA) system is the most polymorphic gene 
      cluster in humans. High-resolution donor-recipient matching for HLA genes 
      improves patient survival after unrelated hematopoietic stem cell 
      transplantation. MATERIALS AND METHODS: In this study, we analyzed the 
      high-resolution allele and haplotype frequencies at the HLA-A, -B and -DRB1 loci 
      in the Liaoning Han population and analyzed its relationships with other 
      populations. RESULTS: The 3 most frequent alleles at the HLA-A, -B and -DRB1 loci 
      were A*24:02, A*02:01:01G, A*11:01; B*13:02, B*46:01, B*40:01:01G; DRB1*09:01, 
      DRB1*15:01 and DRB1*07:01, respectively. The most frequent 2-locus haplotypes 
      were A*30:01-B*13:02 and B*13:02-DRB1*07:01. A*30:01-B*13:02-DRB1*07:01 was 
      determined to be the predominant 3-locus haplotype. Hot maps and multiple 
      correspondence analyses based on the frequencies of HLA specificities, which 
      allow statistical visualization of dependent and independent relationships among 
      variables, indicate that the Liaoning Han population is closely related to 
      Northern populations of China and shows relative close relationships with Asian 
      populations. CONCLUSION: These data will provide an outline of the HLA 
      characteristics of healthy individuals in our region and help bone marrow 
      transplantation patients find suitable HLA-matched donors.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Shao, L-N
AU  - Shao LN
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Zhang, S-T
AU  - Zhang ST
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Yu, W-J
AU  - Yu WJ
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Zhou, S-H
AU  - Zhou SH
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Duan, Y
AU  - Duan Y
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Pan, L-Z
AU  - Pan LZ
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Wang, N
AU  - Wang N
AD  - Dalian Blood Center, Dalian, Liaoning, China.
FAU - Liu, M
AU  - Liu M
AUID- ORCID: 0000-0002-6749-8013
AD  - Department of Cell Biology, Dalian Medical University, Dalian, China.
LA  - eng
PT  - Journal Article
DEP - 20170312
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B protein, human)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People
MH  - Bone Marrow Transplantation
MH  - China
MH  - Exons
MH  - Gene Expression
MH  - *Gene Frequency
MH  - HLA-A Antigens/classification/*genetics/immunology
MH  - HLA-B27 Antigen/classification/*genetics/immunology
MH  - HLA-DRB1 Chains/classification/*genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Sequence Analysis, DNA
MH  - *Tissue Donors
MH  - White People
OTO - NOTNLM
OT  - allele frequency
OT  - haplotype frequency
OT  - high-resolution
OT  - human leukocyte antigen
OT  - population relationship
EDAT- 2017/03/16 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2017/01/29 00:00 [revised]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 10.1111/tan.13006 [doi]
PST - ppublish
SO  - HLA. 2017 May;89(5):293-300. doi: 10.1111/tan.13006. Epub 2017 Mar 12.