PMID- 28296528 OWN - NLM STAT- MEDLINE DCOM- 20180109 LR - 20220409 IS - 1362-301X (Electronic) IS - 0269-9052 (Linking) VI - 31 IP - 3 DP - 2017 TI - The impact of early hyperglycaemia on children with traumatic brain injury. PG - 396-400 LID - 10.1080/02699052.2016.1264629 [doi] AB - OBJECTIVE: Hyperglycaemia is common amongst children with traumatic brain injury (TBI). We aim to investigate the association between early hyperglycaemia and poor clinical outcomes in children with moderate to severe TBI. METHODS: We performed a retrospective study in a tertiary paediatric hospital between May 2012 and October 2014 of all patients with TBI who were aged <16 years with a Glasgow Coma Scale (GCS) of 11.1 mmol/L (200 mg/dL). RESULTS: There were 109 patients with a median age of 54 months [inter-quartile range (IQR): 17-82]. Median glucose on arrival was 6.1 mmol/L (IQR: 5.2-9.8). Median GCS in our cohort was 8 (IQR: 6-12). Multivariate logistic regression demonstrated that initial hyperglycaemia [odds ratio (OR): 15.23; 95% confidence interval (CI): 3.74-62.00; P < 0.001], and GCS <8 (OR: 13.02; 95% CI: 2.31-73.33; P = 0.004) were risk factors for mortality. Multivariate linear regression showed that initial hyperglycaemia was a risk factor for reduced ventilation-free, PICU-free and hospital-free days. CONCLUSIONS: Early hyperglycaemia predicts for in-hospital mortality, reduced ventilation-free, PICU-free and hospital-free days in children with moderate to severe TBI. FAU - Fu, Yue-Qiang AU - Fu YQ AD - a Department of Critical Care Medicine, Children's Hospital , Chongqing Medical University , Chongqing , China. FAU - Chong, Shu-Ling AU - Chong SL AD - b Department of Children's Emergency , KK Women's and Children's Hospital , Singapore , Singapore. AD - c Duke-NUS Medical School , Singapore , Singapore. FAU - Lee, Jan Hau AU - Lee JH AD - c Duke-NUS Medical School , Singapore , Singapore. AD - d Children's Intensive Care Unit , KK Women's and Children's Hospital , Singapore , Singapore. FAU - Liu, Cheng-Jun AU - Liu CJ AD - a Department of Critical Care Medicine, Children's Hospital , Chongqing Medical University , Chongqing , China. FAU - Fu, Sheng AU - Fu S AD - e Department of Paediatrics , KK Women's and Children's Hospital , Singapore , Singapore. FAU - Loh, Tsee Foong AU - Loh TF AD - c Duke-NUS Medical School , Singapore , Singapore. AD - d Children's Intensive Care Unit , KK Women's and Children's Hospital , Singapore , Singapore. FAU - Ng, Kee Chong AU - Ng KC AD - b Department of Children's Emergency , KK Women's and Children's Hospital , Singapore , Singapore. AD - c Duke-NUS Medical School , Singapore , Singapore. FAU - Xu, Feng AU - Xu F AD - a Department of Critical Care Medicine, Children's Hospital , Chongqing Medical University , Chongqing , China. LA - eng PT - Journal Article DEP - 20170216 PL - England TA - Brain Inj JT - Brain injury JID - 8710358 RN - 0 (Blood Glucose) SB - IM MH - Blood Glucose/metabolism MH - Brain Injuries, Traumatic/*complications/mortality MH - Child MH - Child, Preschool MH - Cohort Studies MH - Female MH - Glasgow Coma Scale MH - *Hospital Mortality MH - Humans MH - Hyperglycemia/*etiology/*mortality MH - Infant MH - Intensive Care Units, Pediatric MH - Length of Stay MH - Linear Models MH - Male MH - Risk Factors MH - Treatment Outcome OTO - NOTNLM OT - Children OT - hyperglycaemia OT - mortality OT - paediatric OT - traumatic brain injury EDAT- 2017/03/16 06:00 MHDA- 2018/01/10 06:00 CRDT- 2017/03/16 06:00 PHST- 2017/03/16 06:00 [entrez] PHST- 2017/03/16 06:00 [pubmed] PHST- 2018/01/10 06:00 [medline] AID - 10.1080/02699052.2016.1264629 [doi] PST - ppublish SO - Brain Inj. 2017;31(3):396-400. doi: 10.1080/02699052.2016.1264629. Epub 2017 Feb 16.