PMID- 28297699
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20170901
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 237
IP  - 3
DP  - 2017
TI  - Value of Microperimetry in Detecting Early Retinal Toxicity of Hydroxychloroquine 
      in Children with Juvenile Systemic Lupus Erythematosus.
PG  - 180-184
LID - 10.1159/000461595 [doi]
AB  - PURPOSE: To evaluate retinal sensitivity in children who are on 
      hydroxychloroquine (HCQ) for systemic lupus erythematosus using microperimetry 
      and compare the results with those of the Humphrey visual field (HVF) 10-2 and 
      spectral-domain optical coherence tomography (SD-OCT). PROCEDURE: A case-control 
      cross-sectional study including 19 patients (less than 18 years old) on HCQ for 
      at least 5 years. Controls were 21 normal children. Participants underwent a 
      complete ophthalmic examination, then were investigated using HVF 10-2, SD-OCT, 
      and microperimetry. RESULTS: Ocular examination revealed no abnormalities. The 
      overall mean microperimetry sensitivity of the patients (15.75 dB) was not 
      significantly different from that of the controls (16.35 dB). The HVF 10-2 showed 
      a significant difference in the mean deviation of the patients. Conclusions and 
      Message: Microperimetry was not more revealing than HVF 10-2 and SD-OCT. Larger 
      studies are required to compare the diagnostic accuracy of screening modalities 
      of retinal toxicity in children on HCQ.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Youssef, Maha M
AU  - Youssef MM
AD  - Ophthalmology and Pediatric Rheumatology Departments, Faculty of Medicine, Cairo 
      University, Cairo, Egypt.
FAU - El-Fayoumi, Dina
AU  - El-Fayoumi D
FAU - Sidky, Mohamed Karim
AU  - Sidky MK
FAU - Hegazy, Ahmed I
AU  - Hegazy AI
FAU - Marzouk, Huda
AU  - Marzouk H
FAU - Eltanamly, Rasha M
AU  - Eltanamly RM
LA  - eng
PT  - Journal Article
DEP - 20170316
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
RN  - 0 (Antirheumatic Agents)
RN  - 4QWG6N8QKH (Hydroxychloroquine)
SB  - IM
MH  - Adolescent
MH  - Antirheumatic Agents/adverse effects/therapeutic use
MH  - Child
MH  - Cross-Sectional Studies
MH  - *Early Diagnosis
MH  - Electroretinography
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Fundus Oculi
MH  - Humans
MH  - Hydroxychloroquine/*adverse effects/therapeutic use
MH  - Lupus Erythematosus, Systemic/*drug therapy
MH  - Male
MH  - Reproducibility of Results
MH  - Retina/drug effects/pathology
MH  - Retinal Diseases/*chemically induced/diagnosis
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
MH  - Visual Field Tests/*methods
EDAT- 2017/03/16 06:00
MHDA- 2017/09/02 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2017/02/09 00:00 [accepted]
PHST- 2017/03/16 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
PHST- 2017/03/16 06:00 [entrez]
AID - 000461595 [pii]
AID - 10.1159/000461595 [doi]
PST - ppublish
SO  - Ophthalmologica. 2017;237(3):180-184. doi: 10.1159/000461595. Epub 2017 Mar 16.