PMID- 28298162
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20231213
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 31
IP  - 7
DP  - 2018 Apr
TI  - Expression and significance of dendritic cells and Th17/Treg in serum and 
      placental tissues of patients with intrahepatic cholestasis of pregnancy.
PG  - 901-906
LID - 10.1080/14767058.2017.1300652 [doi]
AB  - PURPOSE: Dendritic cells (DCs) are involved in immune system, which can also 
      regulate the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). 
      DCs and Th17/Treg participate in preeclampsia and recurrent spontaneous abortion 
      (RSA), but there is still lack of research in intrahepatic cholestasis of 
      pregnancy (ICP). The aim was to evaluate the expression and significance of 
      CD83(+)DCs, CD1a(+)DCs, interleukin-17 (IL-17) and IL-35 in serum and placental 
      tissues of patients with ICP. METHODS: Thirty cases of mild ICP, 25 cases of 
      severe ICP were selected, and 30 cases of normal pregnant women were selected as 
      control group. Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry 
      (IHC) were used to detect the expression of CD83(+)DCs, CD1a(+)DCs, IL-17 and 
      IL-35 in serum and placenta tissues, respectively. RESULTS: There were more 
      CD83(+)DCs, IL-17 expressed in placenta from women with ICP than in normal 
      pregnancies, while the number of decidual CD1a(+)DCs, IL-35 was significantly 
      lower in ICP than in normal pregnant women. The comparison within three groups 
      had statistical difference (p < .05). Serum CD83(+)DCs and CD1a(+)DCs levels had 
      no significance. IL-17 was higher in ICP, while IL-35 was lower. CONCLUSIONS: DCs 
      are involved in damaging the maternal-fetal immune tolerance by changing the 
      phenotype and mature state, which may affect the differentiation of Th17/Treg to 
      cause ICP.
FAU - Kong, Xiang
AU  - Kong X
AUID- ORCID: 0000-0002-9657-250X
AD  - a Department of Obstetrics and Gynecology , Medical College of Yangzhou 
      University , Yangzhou , China.
FAU - Kong, Yan
AU  - Kong Y
AD  - a Department of Obstetrics and Gynecology , Medical College of Yangzhou 
      University , Yangzhou , China.
FAU - Zhang, Fangyuan
AU  - Zhang F
AD  - a Department of Obstetrics and Gynecology , Medical College of Yangzhou 
      University , Yangzhou , China.
FAU - Wang, Tingting
AU  - Wang T
AD  - a Department of Obstetrics and Gynecology , Medical College of Yangzhou 
      University , Yangzhou , China.
FAU - Zhu, Xiaotong
AU  - Zhu X
AD  - a Department of Obstetrics and Gynecology , Medical College of Yangzhou 
      University , Yangzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20170315
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (Immunoglobulins)
RN  - 0 (Interleukin-17)
RN  - 0 (Membrane Glycoproteins)
RN  - Intrahepatic Cholestasis of Pregnancy
SB  - IM
MH  - Analysis of Variance
MH  - Antigens, CD/metabolism
MH  - Antigens, CD1/genetics/*metabolism
MH  - Case-Control Studies
MH  - Cholestasis, Intrahepatic/blood/classification/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulins/metabolism
MH  - Interleukin-17/genetics/metabolism
MH  - Membrane Glycoproteins/metabolism
MH  - Placenta/*immunology/pathology
MH  - Pregnancy
MH  - Pregnancy Complications/blood/classification/*immunology
MH  - Th17 Cells/*immunology
MH  - CD83 Antigen
OTO - NOTNLM
OT  - CD1a+DCs
OT  - CD83+DCs
OT  - Th17/Treg
OT  - immune tolerance
OT  - intrahepatic cholestasis of pregnancy
EDAT- 2017/03/17 06:00
MHDA- 2018/08/07 06:00
CRDT- 2017/03/17 06:00
PHST- 2017/03/17 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
PHST- 2017/03/17 06:00 [entrez]
AID - 10.1080/14767058.2017.1300652 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2018 Apr;31(7):901-906. doi: 
      10.1080/14767058.2017.1300652. Epub 2017 Mar 15.