PMID- 28299606
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 9
DP  - 2017 Sep
TI  - Three-dimensional speckle tracking longitudinal strain is related to myocardial 
      fibrosis determined by late-gadolinium enhancement.
PG  - 1351-1360
LID - 10.1007/s10554-017-1115-1 [doi]
AB  - Three-dimensional (3D) speckle tracking echocardiography (STE) is a reliable 
      clinical tool for accurate measurements of left ventricular (LV) volumes and 
      ejection fraction (EF). In this prospective study, we sought to identify an 
      association between 3DSTE longitudinal strain abnormalities and areas of late 
      gadolinium enhancement (LGE). In 50 patients (52 +/- 18.5 years old) referred to 
      our hospital for clinically indicated CMR, 3D full-volume trans-thoracic 
      acquisitions on apical views were performed within 1 h of CMR, in order to obtain 
      LV volumes and ejection fraction as well as global and segmental peak systolic 
      longitudinal strain. Relative amount of fibrosis was defined based on LGE CMR 
      with grey-scale threshold of 5 standard deviations above the mean signal 
      intensity of the normal remote myocardium. We found a moderate positive 
      correlation between global longitudinal strain (GLS) by 3DSTE and LGE proportion 
      (r = 0.465, p = 0.001). The area under the receiver operating characteristic 
      curve was 0.79. In addition, abnormal GLS could detect LGE-determined myocardial 
      fibrosis with a sensitivity of 84.6%, a specificity of 84.8%, a positive 
      predictive value of 69% and negative predictive value of 93%, considering an 
      optimal GLS cut-off value of - 15.25%. Regarding 3DSTE capacity of localizing 
      segmental LGE involvement, about 70% of LGE-positive segments presented a 
      concomitant longitudinal strain reduction. This prospective study shows that 
      3DSTE longitudinal deformation is moderately associated with the extent of 
      myocardial fibrosis, with a promising potential role in ruling out prognostically 
      relevant fibrosis as detected by LGE.
FAU - Spartera, Marco
AU  - Spartera M
AUID- ORCID: 0000-0002-8991-3396
AD  - Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Via 
      Olgettina 60, 20132, Milan, Italy. marco.spartera@gmail.com.
FAU - Damascelli, Anna
AU  - Damascelli A
AD  - Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Via 
      Olgettina 60, 20132, Milan, Italy.
FAU - Mozes, Ferenc
AU  - Mozes F
AD  - University of Oxford, Oxford, UK.
FAU - De Cobelli, Francesco
AU  - De Cobelli F
AD  - Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Via 
      Olgettina 60, 20132, Milan, Italy.
FAU - La Canna, Giovanni
AU  - La Canna G
AD  - Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Via 
      Olgettina 60, 20132, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170315
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Biomechanical Phenomena
MH  - Cardiomyopathies/*diagnostic imaging/pathology/physiopathology
MH  - Contrast Media/*administration & dosage
MH  - *Echocardiography, Three-Dimensional
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - Myocardium/*pathology
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Stress, Mechanical
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/pathology/physiopathology
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Late gadolinium enhancement
OT  - Longitudinal strain
OT  - Myocardial fibrosis
OT  - Three-dimensional speckle tracking echocardiography
OT  - Tissue characterization
EDAT- 2017/03/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/03/17 06:00
PHST- 2017/01/25 00:00 [received]
PHST- 2017/03/09 00:00 [accepted]
PHST- 2017/03/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/03/17 06:00 [entrez]
AID - 10.1007/s10554-017-1115-1 [pii]
AID - 10.1007/s10554-017-1115-1 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 Sep;33(9):1351-1360. doi: 
      10.1007/s10554-017-1115-1. Epub 2017 Mar 15.