PMID- 28299856
OWN - NLM
STAT- MEDLINE
DCOM- 20180810
LR  - 20180810
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Linking)
VI  - 102
IP  - 1
DP  - 2018 Feb
TI  - Effects of a short-term supranutritional selenium supplementation on redox 
      balance, physiology and insulin-related metabolism in heat-stressed pigs.
PG  - 276-285
LID - 10.1111/jpn.12689 [doi]
AB  - Heat stress (HS) disrupts redox balance and insulin-related metabolism. 
      Supplementation with supranutritional amounts of selenium (Se) may enhance 
      glutathione peroxidase (GPX) activity and reduce oxidative stress, but may 
      trigger insulin resistance. Therefore, the aim of this experiment was to 
      investigate the effects of a short-term high Se supplementation on physiology, 
      oxidative stress and insulin-related metabolism in heat-stressed pigs. 
      Twenty-four gilts were fed either a control (0.20 ppm Se) or a high Se (1.0 ppm 
      Se yeast, HiSe) diet for 2 weeks. Pigs were then housed in thermoneutral (20 degrees C) 
      or HS (35 degrees C) conditions for 8 days. Blood samples were collected to study blood 
      Se and oxidative stress markers. An oral glucose tolerance test (OGTT) was 
      conducted on day 8 of thermal exposure. The HS conditions increased rectal 
      temperature and respiration rate (both p < .001). The HiSe diet increased blood 
      Se by 12% (p < .05) and ameliorated the increase in rectal temperature (p < .05). 
      Heat stress increased oxidative stress as evidenced by a 48% increase in plasma 
      advanced oxidized protein products (AOPPs; p < .05), which may be associated with 
      the reductions in plasma biological antioxidant potential (BAP) and erythrocyte 
      GPX activity (both p < .05). The HiSe diet did not alleviate the reduction in 
      plasma BAP or increase in AOPPs observed during HS, although it tended to 
      increase erythrocyte GPX activity by 13% (p = .068). Without affecting insulin, 
      HS attenuated lipid mobilization, as evidenced by a lower fasting NEFA 
      concentration (p < .05), which was not mitigated by the HiSe diet. The HiSe diet 
      increased insulin AUC, suggesting it potentiated insulin resistance, although 
      this only occurred under TN conditions (p = .066). In summary, HS induced 
      oxidative stress and attenuated lipid mobilization in pigs. The short-term 
      supranutritional Se supplementation alleviated hyperthermia, but did not protect 
      against oxidative stress in heat-stressed pigs.
CI  - (c) 2017 Blackwell Verlag GmbH.
FAU - Liu, F
AU  - Liu F
AUID- ORCID: 0000-0003-2644-2416
AD  - Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Celi, P
AU  - Celi P
AD  - Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
AD  - DSM Nutritional Products, Columbia, MD, USA.
FAU - Cottrell, J J
AU  - Cottrell JJ
AD  - Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Chauhan, S S
AU  - Chauhan SS
AD  - Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Leury, B J
AU  - Leury BJ
AD  - Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Dunshea, F R
AU  - Dunshea FR
AD  - Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170316
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Dietary Supplements
MH  - Erythrocytes/enzymology
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Glucose Tolerance Test
MH  - Glutathione Peroxidase/metabolism
MH  - Heat Stress Disorders/complications/drug therapy/*veterinary
MH  - Insulin/*metabolism
MH  - Oxidation-Reduction
MH  - Selenium/administration & dosage/*pharmacology
MH  - Swine
MH  - Swine Diseases/etiology/*prevention & control
OTO - NOTNLM
OT  - heat stress
OT  - insulin
OT  - oxidative stress
OT  - physiology
OT  - pig
OT  - selenium
EDAT- 2017/03/17 06:00
MHDA- 2018/08/11 06:00
CRDT- 2017/03/17 06:00
PHST- 2016/10/22 00:00 [received]
PHST- 2017/01/10 00:00 [accepted]
PHST- 2017/03/17 06:00 [pubmed]
PHST- 2018/08/11 06:00 [medline]
PHST- 2017/03/17 06:00 [entrez]
AID - 10.1111/jpn.12689 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2018 Feb;102(1):276-285. doi: 10.1111/jpn.12689. 
      Epub 2017 Mar 16.