PMID- 2829990
OWN - NLM
STAT- MEDLINE
DCOM- 19880325
LR  - 20191210
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 436
IP  - 2
DP  - 1987 Dec 15
TI  - Motivational properties of opioids: evidence that an activation of 
      delta-receptors mediates reinforcement processes.
PG  - 234-9
AB  - The role of central delta-opioid receptors in the mediation of opioid 
      reinforcement and endogenous reward processes was examined using a non-biased 
      place-preference conditioning procedure. Intracerebroventricular (i.c.v.) 
      administration of the selective delta-receptor agonist, [D-Pen2, 
      D-Pen5]-enkephalin (DPDPE, 10.0-25.0 micrograms) produced a significant 
      preference for the drug-associated place and a similar effect was observed 
      following i.c.v. injections of morphine (10.0 micrograms). Administration of the 
      delta-receptor antagonist, ICI 174,864, at doses (1.0-5.0 micrograms, i.c.v.) 
      which had no aversive effects when tested alone, abolished the reinforcing 
      properties of DPDPE. Such treatment did not, however, modify the effect of 
      morphine. These findings demonstrate the involvement delta- as well as 
      mu-receptors in the motivational properties of opioids and suggest that the 
      activation of either receptor type is sufficient for the elicitation of 
      appetitively reinforcing effects.
FAU - Shippenberg, T S
AU  - Shippenberg TS
AD  - Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, 
      Planegg-Martinsried, F.R.G.
FAU - Bals-Kubik, R
AU  - Bals-Kubik R
FAU - Herz, A
AU  - Herz A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 76I7G6D29C (Morphine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
RN  - 89352-67-0 (N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine)
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/drug effects
MH  - Avoidance Learning/drug effects
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalin, Leucine/administration & dosage/*analogs & derivatives/pharmacology
MH  - Enkephalins/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Morphine/administration & dosage/*pharmacology
MH  - Motivation/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Opioid/drug effects/*physiology
MH  - Receptors, Opioid, delta
MH  - *Reinforcement, Psychology
EDAT- 1987/12/15 00:00
MHDA- 1987/12/15 00:01
CRDT- 1987/12/15 00:00
PHST- 1987/12/15 00:00 [pubmed]
PHST- 1987/12/15 00:01 [medline]
PHST- 1987/12/15 00:00 [entrez]
AID - 0006-8993(87)91667-2 [pii]
AID - 10.1016/0006-8993(87)91667-2 [doi]
PST - ppublish
SO  - Brain Res. 1987 Dec 15;436(2):234-9. doi: 10.1016/0006-8993(87)91667-2.