PMID- 28300570
OWN - NLM
STAT- MEDLINE
DCOM- 20170831
LR  - 20181115
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 152
IP  - 1
DP  - 2017 Jul
TI  - Idiopathic Interstitial Pneumonia Associated With Autoantibodies: A Large Case 
      Series Followed Over 1 Year.
PG  - 103-112
LID - S0012-3692(17)30364-1 [pii]
LID - 10.1016/j.chest.2017.03.004 [doi]
AB  - BACKGROUND: Some patients with autoimmune characteristics and idiopathic 
      interstitial pneumonia, particularly usual interstitial pneumonia (UIP), do not 
      fit neatly into the category of connective tissue disease-associated interstitial 
      lung disease (CTD-ILD), idiopathic pulmonary fibrosis (IPF), or recently proposed 
      yet to be validated criteria for interstitial pneumonia with autoimmune features 
      (IPAF). Outcomes of these patients are unknown. METHODS: This was a retrospective 
      single-center study. Analyses of variance compared differences in mean change in 
      FVC and diffusion capacity (Dlco) over 1 year among 124 well-defined patients (20 
      patients with positive autoantibodies with or without symptoms of connective 
      tissue disease [AI-ILD], 15 patients with IPAF, 36 patients with CTD-ILD, and 53 
      patients with IPF with negative CTD serologies [Lone-IPF]). RESULTS: Of the 
      patients, 75% with AI-ILD, 33% with IPAF, and 33% with CTD-ILD had UIP. Initial 
      FVC and Dlco were similarly moderately reduced across groups. Mean change in FVC 
      over 12 months was as follows: -60 mL (IPAF), -110 mL (AI-ILD), -10 mL (CTD-ILD), 
      and -90 mL (Lone-IPF) (P = .52). Mean change in Dlco was as follows: 
      2.39 mL/mm Hg/min (IPAF), -1.15 mL/mm Hg/min (AI-ILD), -0.27 mL/mm Hg/min 
      (CTD-ILD), and -1.05 mL/mm Hg/min (Lone-IPF) (P < .001). By pattern of disease, 
      the mean change in FVC was as follows: -140 mL (UIP), 10 mL (nonspecific 
      interstitial pneumonia), and 12 mL (unclassifiable/other) (P = .001). 
      CONCLUSIONS: No clinically significant differences in pulmonary function to 
      distinguish between patients with AI-ILD, IPAF, CTD-ILD, and Lone-IPF were 
      observed after 1 year. Longer periods of follow-up are needed to understand the 
      outcomes of these patients. It is not yet clear whether AI-ILD is a distinct 
      phenotype or a variant of the newly proposed entity IPAF.
CI  - Copyright (c) 2017 American College of Chest Physicians. Published by Elsevier Inc. 
      All rights reserved.
FAU - Collins, Bridget F
AU  - Collins BF
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA.
FAU - Spiekerman, Charles F
AU  - Spiekerman CF
AD  - Institute of Translational Health Sciences, University of Washington Medical 
      Center, Seattle, WA.
FAU - Shaw, Megan A
AU  - Shaw MA
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA.
FAU - Ho, Lawrence A
AU  - Ho LA
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA.
FAU - Hayes, Jennifer
AU  - Hayes J
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA.
FAU - Spada, Carolyn A
AU  - Spada CA
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA.
FAU - Stamato, Caroline M
AU  - Stamato CM
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA.
FAU - Raghu, Ganesh
AU  - Raghu G
AD  - Center for Interstitial Lung Diseases, University of Washington Medical Center, 
      Seattle, WA. Electronic address: graghu@uw.edu.
LA  - eng
GR  - UL1 TR000423/TR/NCATS NIH HHS/United States
GR  - UL1 TR002319/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170312
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Aged
MH  - Autoantibodies/*blood
MH  - Autoimmunity/immunology
MH  - Cohort Studies
MH  - *Connective Tissue Diseases/diagnosis/physiopathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Idiopathic Interstitial 
      Pneumonias/diagnosis/epidemiology/immunology/physiopathology
MH  - *Idiopathic Pulmonary Fibrosis/diagnosis/immunology/physiopathology
MH  - Lung/diagnostic imaging/physiopathology
MH  - *Lung Diseases, Interstitial/diagnosis/immunology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Needs Assessment
MH  - Respiratory Function Tests/methods
MH  - Statistics as Topic
MH  - Tomography, X-Ray Computed/methods
MH  - Washington/epidemiology
PMC - PMC6026269
OTO - NOTNLM
OT  - autoimmune interstitial lung disease
OT  - idiopathic pulmonary fibrosis
OT  - interstitial lung disease
OT  - interstitial pneumonia with autoimmune features
EDAT- 2017/03/17 06:00
MHDA- 2017/09/01 06:00
PMCR- 2018/07/01
CRDT- 2017/03/17 06:00
PHST- 2016/09/23 00:00 [received]
PHST- 2017/02/01 00:00 [revised]
PHST- 2017/03/01 00:00 [accepted]
PHST- 2017/03/17 06:00 [pubmed]
PHST- 2017/09/01 06:00 [medline]
PHST- 2017/03/17 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - S0012-3692(17)30364-1 [pii]
AID - 10.1016/j.chest.2017.03.004 [doi]
PST - ppublish
SO  - Chest. 2017 Jul;152(1):103-112. doi: 10.1016/j.chest.2017.03.004. Epub 2017 Mar 
      12.