PMID- 28301075 OWN - NLM STAT- MEDLINE DCOM- 20180716 LR - 20190105 IS - 1522-2586 (Electronic) IS - 1053-1807 (Print) IS - 1053-1807 (Linking) VI - 46 IP - 6 DP - 2017 Dec TI - Clinical performance of high-resolution late gadolinium enhancement imaging with compressed sensing. PG - 1829-1838 LID - 10.1002/jmri.25695 [doi] AB - PURPOSE: To evaluate diagnostic image quality of 3D late gadolinium enhancement (LGE) with high isotropic spatial resolution ( approximately 1.4 mm(3) ) images reconstructed from randomly undersampled k-space using LOw-dimensional-structure Self-learning and Thresholding (LOST). MATERIALS AND METHODS: We prospectively enrolled 270 patients (181 men; 55 +/- 14 years) referred for myocardial viability assessment. 3D LGE with isotropic spatial resolution of 1.4 +/- 0.1 mm(3) was acquired at 1.5T using a LOST acceleration rate of 3 to 5. In a subset of 121 patients, 3D LGE or phase-sensitive LGE were acquired with parallel imaging with an acceleration rate of 2 for comparison. Two readers evaluated image quality using a scale of 1 (poor) to 4 (excellent) and assessed for scar presence. The McNemar test statistic was used to compare the proportion of detected scar between the two sequences. We assessed the association between image quality and characteristics (age, gender, torso dimension, weight, heart rate), using generalized linear models. RESULTS: Overall, LGE detection proportions for 3D LGE with LOST were similar between readers 1 and 2 (16.30% vs. 18.15%). For image quality, readers gave 85.9% and 80.0%, respectively, for images categorized as good or excellent. Overall proportion of scar presence was not statistically different from conventional 3D LGE (28% vs. 33% [P = 0.17] for reader 1 and 26% vs. 31% [P = 0.37] for reader 2). Increasing subject heart rate was associated with lower image quality (estimated slope = -0.009 (P = 0.001)). CONCLUSION: High-resolution 3D LGE with LOST yields good to excellent image quality in >80% of patients and identifies patients with LV scar at the same rate as conventional 3D LGE. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1829-1838. CI - (c) 2017 International Society for Magnetic Resonance in Medicine. FAU - Basha, Tamer A AU - Basha TA AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. AD - Systems and Biomedical Engineering Department, University of Cairo, Cairo, Egypt. FAU - Akcakaya, Mehmet AU - Akcakaya M AD - Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, USA. AD - Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Liew, Charlene AU - Liew C AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Tsao, Connie W AU - Tsao CW AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Delling, Francesca N AU - Delling FN AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Addae, Gifty AU - Addae G AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Ngo, Long AU - Ngo L AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Manning, Warren J AU - Manning WJ AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Nezafat, Reza AU - Nezafat R AD - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - R01 HL129185/HL/NHLBI NIH HHS/United States GR - R01 HL127015/HL/NHLBI NIH HHS/United States GR - R21 HL127650/HL/NHLBI NIH HHS/United States GR - R00 HL111410/HL/NHLBI NIH HHS/United States GR - K99 HL111410/HL/NHLBI NIH HHS/United States GR - R01 EB008743/EB/NIBIB NIH HHS/United States GR - R01 HL129157/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20170316 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Contrast Media MH - Female MH - *Gadolinium MH - Heart/diagnostic imaging MH - Heart Diseases/*diagnostic imaging MH - Humans MH - Image Enhancement/*methods MH - Image Interpretation, Computer-Assisted/methods MH - Image Processing, Computer-Assisted/*methods MH - Imaging, Three-Dimensional/methods MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Prospective Studies MH - Young Adult PMC - PMC5600642 MID - NIHMS853933 OTO - NOTNLM OT - compressed sensing OT - late gadolinium enhancement OT - myocardial viability EDAT- 2017/03/17 06:00 MHDA- 2018/07/17 06:00 PMCR- 2018/12/01 CRDT- 2017/03/17 06:00 PHST- 2016/03/28 00:00 [received] PHST- 2017/02/15 00:00 [accepted] PHST- 2017/03/17 06:00 [pubmed] PHST- 2018/07/17 06:00 [medline] PHST- 2017/03/17 06:00 [entrez] PHST- 2018/12/01 00:00 [pmc-release] AID - 10.1002/jmri.25695 [doi] PST - ppublish SO - J Magn Reson Imaging. 2017 Dec;46(6):1829-1838. doi: 10.1002/jmri.25695. Epub 2017 Mar 16.