PMID- 28301147
OWN - NLM
STAT- MEDLINE
DCOM- 20170804
LR  - 20181107
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 51
IP  - 8
DP  - 2017 Apr 18
TI  - Exposure to Persistent Organic Pollutants Reduces Testosterone Concentrations and 
      Affects Sperm Viability and Morphology during the Mating Peak Period in a 
      Controlled Experiment on Farmed Arctic Foxes (Vulpes lagopus).
PG  - 4673-4680
LID - 10.1021/acs.est.7b00289 [doi]
AB  - We investigated testosterone production and semen parameters in farmed Arctic 
      foxes by dietary exposure to persistent organic pollutants (POPs) for 22 months. 
      Eight male foxes were given a diet of POP-contaminated minke whale blubber, 
      whereas their eight male siblings were fed a control diet containing pig fat as 
      the main fat source. The minke whale-based feed contained a  summation operatorPOPs concentration 
      of 802 ng/g ww, whereas the pig-based feed contained  summation operatorPOPs of 24 ng/g ww. At the 
      end of the experiment,  summation operatorPOP concentrations in adipose tissue were 8856 +/- 2535 
      ng/g ww in the exposed foxes and 1264 +/- 539 ng/g ww in the control foxes. The 
      exposed group had 45-64% significantly lower testosterone concentrations during 
      their peak mating season compared to the controls (p </= 0.05), while the number of 
      dead and defect sperm cells was 27% (p = 0.07) and 15% (p = 0.33) higher in the 
      exposed group. Similar effects during the mating season in wild Arctic foxes may 
      affect mating behavior and reproductive success. On the basis of these results, 
      we recommend testosterone as a sensitive biomarker of POP exposure and that 
      seasonal patterns are investigated when interpreting putative endocrine 
      disruption in Arctic wildlife with potential population-level effects.
FAU - Sonne, Christian
AU  - Sonne C
AUID- ORCID: 0000-0001-5723-5263
AD  - Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, 
      Faculty of Science and Technology , Frederiksborgvej 399, P.O. Box 358, DK-4000 
      Roskilde, Denmark.
FAU - Torjesen, Peter A
AU  - Torjesen PA
AD  - Department of Endocrinology, Hormone Laboratory , Oslo University Hospital, 
      NO-0514 Oslo, Norway.
FAU - Fuglei, Eva
AU  - Fuglei E
AD  - Norwegian Polar Institute , Fram Centre, NO-9296 Tromso, Norway.
FAU - Muir, Derek C G
AU  - Muir DCG
AUID- ORCID: 0000-0001-6631-9776
AD  - Aquatic Contaminants Research Division, Environment and Climate Change Canada , 
      Burlington, Ontario, Canada L7S 1A1.
FAU - Jenssen, Bjorn Munro
AU  - Jenssen BM
AD  - Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, 
      Faculty of Science and Technology , Frederiksborgvej 399, P.O. Box 358, DK-4000 
      Roskilde, Denmark.
AD  - Department of Biology, Norwegian University of Science and Technology , NO-7491 
      Trondheim, Norway.
AD  - Department of Arctic Technology, The University Centre in Svarbard , P.O. Box 
      156, NO-9171 Longyearbyen, Norway.
FAU - Jorgensen, Even H
AU  - Jorgensen EH
AD  - Department of Arctic and Marine Biology, UiT the Arctic University of Norway , 
      NO-9037 Tromso, Norway.
FAU - Dietz, Rune
AU  - Dietz R
AD  - Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, 
      Faculty of Science and Technology , Frederiksborgvej 399, P.O. Box 358, DK-4000 
      Roskilde, Denmark.
FAU - Ahlstrom, Oystein
AU  - Ahlstrom O
AD  - Department of Animal and Aquacultural Sciences, Norwegian University of Life 
      Sciences , NO-1433 As, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170330
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Arctic Regions
MH  - Cell Survival/drug effects
MH  - *Environmental Pollutants
MH  - Foxes
MH  - Male
MH  - Spermatozoa/drug effects/physiology
MH  - Swine
MH  - Testosterone/*metabolism
EDAT- 2017/03/17 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/03/17 06:00
PHST- 2017/03/17 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2017/03/17 06:00 [entrez]
AID - 10.1021/acs.est.7b00289 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2017 Apr 18;51(8):4673-4680. doi: 10.1021/acs.est.7b00289. 
      Epub 2017 Mar 30.