PMID- 28301802
OWN - NLM
STAT- MEDLINE
DCOM- 20170607
LR  - 20191210
IS  - 1532-8384 (Electronic)
IS  - 0010-440X (Linking)
VI  - 75
DP  - 2017 May
TI  - Illness severity and biomarkers in depression: Using a unidimensional rating 
      scale to examine BDNF.
PG  - 46-52
LID - S0010-440X(17)30002-0 [pii]
LID - 10.1016/j.comppsych.2017.02.014 [doi]
AB  - BACKGROUND: Numerous studies have reported reduced peripheral brain-derived 
      neurotrophic factor (BDNF) in major depression (MD). However, most of these 
      studies used multidimensional depression rating scales, and failed to identify a 
      relationship between BDNF levels and depression severity. Unidimensional scales 
      are a more valid measure of syndrome severity. In these scales, items are ordered 
      in increasing severity, so that as scores increase, syndrome severity increases; 
      thus, each item adds unique information, and items can be totaled to a meaningful 
      sum. The current study used the HAM-D6, a unidimensional measure of depression, 
      to examine if it could identify a correlation between serum BDNF and depression 
      severity. METHODS: Serum BDNF levels and symptom severity were assessed in 163 
      depressed patients, including those with both unipolar (84.0%) and bipolar 
      (16.0%) depression. The evaluation of depression severity included the total 
      HAM-D17 and 3 subscales, including the HAM-D6. RESULTS: On average, patients 
      presented moderate to severe depression (HAM-D17=21.2+/-5.5). Overall BDNF levels 
      were 60.4+/-22.6ng/mL. The correlation between serum BDNF and depression severity 
      was modest and not different when assessed by the HAM-D6 subscale or the HAM-D17 
      as a whole (z=0.951; p=0.341), despite being statistically significant for the 
      HAM-D6 (r=-0.185; p=0.019; 95% CI: -0.335 to -0.033), but not for the entire 
      HAM-D17 (r=-0.127; p=0.108; 95% CI: -0.272 to 0.027). CONCLUSION: We could not 
      identify a strong relationship between serum BDNF levels and depression severity 
      using the HAM-D6. This is in concordance with results of previous studies that 
      reported no correlation between these variables, and indicates that the 
      properties of the clinical measures used cannot explain the results these 
      studies.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Caldieraro, Marco A
AU  - Caldieraro MA
AD  - Hospital de Clinicas de Porto Alegre, Department of Psychiatry, Porto Alegre, 
      Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Department of 
      Psychiatry and Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: 
      Psiquiatria, Porto Alegre, Brazil. Electronic address: mcaldieraro@hcpa.edu.br.
FAU - Vares, Edgar A
AU  - Vares EA
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Department of Psychiatry and 
      Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Porto 
      Alegre, Brazil.
FAU - Souza, Livia H
AU  - Souza LH
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Department of Psychiatry and 
      Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Porto 
      Alegre, Brazil.
FAU - Spanemberg, Lucas
AU  - Spanemberg L
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Department of Psychiatry and 
      Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Porto 
      Alegre, Brazil; Hospital Sao Lucas da Pontificia Universidade Catolica do Rio 
      Grande do Sul (PUCRS), Department of Psychiatry, Porto Alegre, Brazil.
FAU - Guerra, Tadeu A
AU  - Guerra TA
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Department of Psychiatry and 
      Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Porto 
      Alegre, Brazil.
FAU - Wollenhaupt-Aguiar, Bianca
AU  - Wollenhaupt-Aguiar B
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pos-Graduacao em 
      Ciencias Biologicas: Bioquimica, Porto Alegre, RS, Brazil.
FAU - Ferrari, Pamela
AU  - Ferrari P
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Department of Psychiatry and 
      Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Porto 
      Alegre, Brazil.
FAU - Nierenberg, Andrew A
AU  - Nierenberg AA
AD  - Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; 
      Harvard Medical School, Boston, MA, USA.
FAU - Fleck, Marcelo P
AU  - Fleck MP
AD  - Hospital de Clinicas de Porto Alegre, Department of Psychiatry, Porto Alegre, 
      Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Department of 
      Psychiatry and Forensic Medicine, Programa de Pos-Graduacao Ciencias Medicas: 
      Psiquiatria, Porto Alegre, Brazil.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170306
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Bipolar Disorder/*blood/psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Psychiatric Status Rating Scales
MH  - *Severity of Illness Index
EDAT- 2017/03/17 06:00
MHDA- 2017/06/08 06:00
CRDT- 2017/03/17 06:00
PHST- 2017/01/03 00:00 [received]
PHST- 2017/02/27 00:00 [revised]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/03/17 06:00 [pubmed]
PHST- 2017/06/08 06:00 [medline]
PHST- 2017/03/17 06:00 [entrez]
AID - S0010-440X(17)30002-0 [pii]
AID - 10.1016/j.comppsych.2017.02.014 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2017 May;75:46-52. doi: 10.1016/j.comppsych.2017.02.014. Epub 
      2017 Mar 6.