PMID- 28302316
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20190124
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 308
DP  - 2017 Jul 15
TI  - Defining nervous system susceptibility during acute and latent herpes simplex 
      virus-1 infection.
PG  - 43-49
LID - S0165-5728(16)30479-9 [pii]
LID - 10.1016/j.jneuroim.2017.02.020 [doi]
AB  - Herpes simplex viruses are neurotropic human pathogens that infect and establish 
      latency in peripheral sensory neurons of the host. Herpes Simplex Virus-1 (HSV-1) 
      readily infects the facial mucosa that can result in the establishment of a 
      latent infection in the sensory neurons of the trigeminal ganglia (TG). From 
      latency, HSV-1 can reactivate and cause peripheral pathology following 
      anterograde trafficking from sensory neurons. Under rare circumstances, HSV-1 can 
      migrate into the central nervous system (CNS) and cause Herpes Simplex 
      Encephalitis (HSE), a devastating disease of the CNS. It is unclear whether HSE 
      is the result of viral reactivation within the TG, from direct primary infection 
      of the olfactory mucosa, or from other infected CNS neurons. Areas of the brain 
      that are susceptible to HSV-1 during acute infection are ill-defined. 
      Furthermore, whether the CNS is a true reservoir of viral latency following 
      clearance of virus during acute infection is unknown. In this context, this 
      review will identify sites within the brain that are susceptible to acute 
      infection and harbor latent virus. In addition, we will also address findings of 
      HSV-1 lytic gene expression during latency and comment on the pathophysiological 
      consequences HSV-1 infection may have on long-term neurologic performance in 
      animal models and humans.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Menendez, Chandra M
AU  - Menendez CM
AD  - Department of Microbiology, Immunology, University of Oklahoma Health Sciences 
      Center, Oklahoma City, OK, USA.
FAU - Carr, Daniel J J
AU  - Carr DJJ
AD  - Department of Microbiology, Immunology, University of Oklahoma Health Sciences 
      Center, Oklahoma City, OK, USA; Department of Ophthalmology, University of 
      Oklahoma Health Sciences Center, Oklahoma City, OK. USA. Electronic address: 
      dan-carr@ouhsc.edu.
LA  - eng
GR  - R01 AI053108/AI/NIAID NIH HHS/United States
GR  - T32 AI007633/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20170308
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
SB  - IM
MH  - Animals
MH  - Disease Susceptibility
MH  - Herpes Simplex/*complications
MH  - Herpesvirus 1, Human/*pathogenicity
MH  - Humans
MH  - Nervous System Diseases/*etiology/*virology
PMC - PMC5474347
MID - NIHMS859973
OTO - NOTNLM
OT  - Acute infection
OT  - HSV-1 neural tropism
OT  - Latent infection
EDAT- 2017/03/18 06:00
MHDA- 2017/08/18 06:00
PMCR- 2018/07/15
CRDT- 2017/03/18 06:00
PHST- 2016/12/23 00:00 [received]
PHST- 2017/02/13 00:00 [revised]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/03/18 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2017/03/18 06:00 [entrez]
PHST- 2018/07/15 00:00 [pmc-release]
AID - S0165-5728(16)30479-9 [pii]
AID - 10.1016/j.jneuroim.2017.02.020 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2017 Jul 15;308:43-49. doi: 10.1016/j.jneuroim.2017.02.020. Epub 
      2017 Mar 8.