PMID- 28303740
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20190304
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Linking)
VI  - 23
IP  - 6
DP  - 2017 Dec
TI  - Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in 
      the Brain.
PG  - 587-604
LID - 10.1177/1073858417697037 [doi]
AB  - Neurotrophins have been intensively studied and have multiple roles in the brain. 
      Neurotrophins are first synthetized as proneurotrophins and then cleaved 
      intracellularly and extracellularly. Increasing evidences demonstrate that 
      proneurotrophins and mature neurotrophins exerts opposing role in the central 
      nervous system. In the present review, we explore the role of nerve growth factor 
      (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and 
      neurotrophin 4 (NT4) and their respective proform in cellular processes related 
      to learning and memory. We focused on their roles in synaptic activity and 
      plasticity in the brain with an emphasis on long-term potentiation, long-term 
      depression, and basal synaptic transmission in the hippocampus and the temporal 
      lobe area. We also discuss new findings on the role of the Val66Met polymorphism 
      on the BDNF propeptide on synaptic activity.
FAU - Gibon, Julien
AU  - Gibon J
AD  - 1 Department of Biology, University of British Columbia, Kelowna, BC, Canada.
FAU - Barker, Philip A
AU  - Barker PA
AD  - 1 Department of Biology, University of British Columbia, Kelowna, BC, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170317
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Humans
MH  - Nerve Growth Factors/*metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Synapses/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - NGF
OT  - NT3
OT  - NT4
OT  - neurotrophins
OT  - proBDNF
OT  - proNGF
OT  - proNT3
OT  - synaptic activity
OT  - synaptic plasticity
EDAT- 2017/03/18 06:00
MHDA- 2019/03/05 06:00
CRDT- 2017/03/18 06:00
PHST- 2017/03/18 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2017/03/18 06:00 [entrez]
AID - 10.1177/1073858417697037 [doi]
PST - ppublish
SO  - Neuroscientist. 2017 Dec;23(6):587-604. doi: 10.1177/1073858417697037. Epub 2017 
      Mar 17.