PMID- 28304362
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 3
DP  - 2017 Mar 17
TI  - BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy 
      Cohort.
LID - 10.3390/ijms18030655 [doi]
LID - 655
AB  - Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive 
      functions including learning and memory. BDNF plays an important role in synaptic 
      plasticity in humans and rats with BDNF shown to be essential for the formation 
      of long-term memories. We previously identified a significant association between 
      the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 
      0.003) in a small cohort (n = 181) comprised of healthy individuals who had been 
      phenotyped for various aspects of memory function. In this study, we have 
      extended the cohort to 597 individuals and examined multiple genetic variants 
      across both the BDNF and BDNF-AS genes for association with visual memory 
      performance as assessed by the Wechsler Memory Scale-Fourth Edition subtests 
      Visual Reproduction I and II (VR I and II). VR I assesses immediate visual 
      memory, whereas VR II assesses long-term visual memory. Genetic association 
      analyses were performed for 34 single nucleotide polymorphisms genotyped on 
      Illumina OmniExpress BeadChip arrays with the immediate and long-term visual 
      memory phenotypes. While none of the BDNF and BDNF-AS variants were shown to be 
      significant for immediate visual memory, we found 10 variants (including the 
      Val66Met polymorphism (p-value = 0.006)) that were nominally associated, and 
      three variants (two variants in BDNF and one variant in the BDNF-AS locus) that 
      were significantly associated with long-term visual memory. Our data therefore 
      suggests a potential role for BDNF, and its anti-sense transcript BDNF-AS, in 
      long-term visual memory performance.
FAU - Avgan, Nesli
AU  - Avgan N
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. nesli.avgan@qut.edu.au.
FAU - Sutherland, Heidi G
AU  - Sutherland HG
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. heidi.sutherland@qut.edu.au.
FAU - Spriggens, Lauren K
AU  - Spriggens LK
AD  - Menzies Health Institute Queensland and School of Applied Psychology, Griffith 
      University, Gold Coast 4222, Australia. l.spriggens@griffith.edu.au.
FAU - Yu, Chieh
AU  - Yu C
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. c22.yu@hdr.qut.edu.au.
FAU - Ibrahim, Omar
AU  - Ibrahim O
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. omarezzedin@gmail.com.
FAU - Bellis, Claire
AU  - Bellis C
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. bellisc@gis.a-star.edu.sg.
AD  - Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and 
      Research of Singapore, Singapore 138672, Singapore. bellisc@gis.a-star.edu.sg.
FAU - Haupt, Larisa M
AU  - Haupt LM
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. larisa.haupt@qut.edu.au.
FAU - Shum, David H K
AU  - Shum DH
AD  - Menzies Health Institute Queensland and School of Applied Psychology, Griffith 
      University, Gold Coast 4222, Australia. d.shum@griffith.edu.au.
FAU - Griffiths, Lyn R
AU  - Griffiths LR
AD  - Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and 
      Biomedical Innovation, School of Biomedical Sciences, Queensland University of 
      Technology, Brisbane 4059, Australia. lyn.griffiths@qut.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20170317
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Memory, Long-Term
MH  - Middle Aged
MH  - *Pattern Recognition, Visual
MH  - *Polymorphism, Single Nucleotide
PMC - PMC5372667
OTO - NOTNLM
OT  - BDNF
OT  - genetics of memory
OT  - human memory
OT  - long-term visual memory
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/18 06:00
MHDA- 2017/04/22 06:00
PMCR- 2017/03/01
CRDT- 2017/03/18 06:00
PHST- 2017/01/31 00:00 [received]
PHST- 2017/03/06 00:00 [revised]
PHST- 2017/03/13 00:00 [accepted]
PHST- 2017/03/18 06:00 [entrez]
PHST- 2017/03/18 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - ijms18030655 [pii]
AID - ijms-18-00655 [pii]
AID - 10.3390/ijms18030655 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Mar 17;18(3):655. doi: 10.3390/ijms18030655.