PMID- 2830586
OWN - NLM
STAT- MEDLINE
DCOM- 19880405
LR  - 20190818
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 7
IP  - 2
DP  - 1988 Feb
TI  - Viral infections in pediatric bone marrow transplant patients.
PG  - 109-15
AB  - The records of 96 pediatric patients with aplastic anemia or a malignancy who 
      underwent bone marrow transplantation between 1979 and 1986 at The Children's 
      Hospital of Philadelphia were reviewed for laboratory evidence of viral 
      infections. The most common viral diseases identified were herpes simplex virus 
      (HSV), cytomegalovirus and adenoviruses, which were found in 19 (20%), 17 (18) 
      and 17 (18) patients, respectively. HSV was more common in patients with than 
      without graft vs. host disease (GVHD) (9 of 30; 30% vs. 10 of 66; 15%), but the 
      difference did not reach statistical significance. Late or prolonged isolation of 
      HSV occurred in patients with chronic GVHD. Cytomegalovirus was significantly 
      more common in patients with than without GVHD (10 of 30; 33% vs. 7 of 66; 11%). 
      The presence of pretransplant antibody to cytomegalovirus or HSV was a good 
      predictor of subsequent infection. Adenoviruses were isolated from all 3 patients 
      with Burkitt's lymphoma. Adenovirus type 12, a serotype uncommon in man and known 
      to be highly tumorigenic in young hamsters, was recovered from 4 patients. 
      Adenoviruses were not notably more common in patients with GVHD (6 of 30; 20% vs. 
      11 of 66; 17%). Other viral infections demonstrated included 5 parainfluenza, 4 
      enteroviruses, 3 human immunodeficiency virus, 1 respiratory syncytial virus, 1 
      influenza B and 1 rhinovirus.
FAU - Wasserman, R
AU  - Wasserman R
AD  - Division of Hematology-Oncology, Children's Hospital of Philadelphia, PA 19104.
FAU - August, C S
AU  - August CS
FAU - Plotkin, S A
AU  - Plotkin SA
LA  - eng
GR  - RR-00240/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
SB  - IM
MH  - Adenovirus Infections, Human/epidemiology
MH  - Adenoviruses, Human/isolation & purification
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Cytomegalovirus/isolation & purification
MH  - Cytomegalovirus Infections/epidemiology
MH  - Female
MH  - Graft vs Host Disease/complications
MH  - Herpes Simplex/epidemiology
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Simplexvirus/isolation & purification
MH  - Virus Diseases/complications/*epidemiology/microbiology
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 10.1097/00006454-198802000-00009 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 1988 Feb;7(2):109-15. doi: 
      10.1097/00006454-198802000-00009.