PMID- 28306135
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20181202
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 65
IP  - 6
DP  - 2017 Jun
TI  - How Common Are Pulmonary and Hepatic Adverse Effects in Older Adults Prescribed 
      Nitrofurantoin?
PG  - 1316-1320
LID - 10.1111/jgs.14796 [doi]
AB  - OBJECTIVES: To determine the frequency of serious pulmonary and hepatic adverse 
      events (AEs) in persons aged 65 and older prescribed nitrofurantoin. DESIGN: 
      Retrospective electronic health record (EHR) audit of nitrofurantoin 
      prescriptions and associated AEs. SETTING: Urban academic medical center. 
      PARTICIPANTS: All inpatients and outpatients aged 65 and older prescribed 
      nitrofurantoin from January 1, 2010, to December 31, 2014. MEASUREMENTS: The 
      number of nitrofurantoin prescriptions and pulmonary and hepatic AEs associated 
      with nitrofurantoin use was acquired by data extraction from EHRs. RESULTS: Of 
      3,400 individuals aged 65 and older prescribed nitrofurantoin during the study 
      period, 641 were identified as possibly having one of five targeted symptoms or 
      disease complications (pulmonary and hepatic) associated with nitrofurantoin. 
      After a detailed chart audit, 89% were deemed to have no adverse reaction, 7% had 
      a minor side effect or allergy, and 3.9% met criteria for suspicion of a 
      nitrofurantoin-induced AE, five of whom were rated as being highly suspicious for 
      nitrofurantoin toxicity; four of the five were identified with pulmonary toxicity 
      and one with hepatotoxicity. Four of five of these individuals used 
      nitrofurantoin chronically. CONCLUSION: Nitrofurantoin was prescribed for 3,400 
      individuals aged 65 and older during the 5-year study period. Serious side 
      effects appeared to be uncommon, but chronic use appeared to be at greater risk.
CI  - (c) 2017, Copyright the Authors Journal compilation (c) 2017, The American Geriatrics 
      Society.
FAU - Claussen, Karin
AU  - Claussen K
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      Dallas, Texas.
FAU - Stocks, Edward
AU  - Stocks E
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      Dallas, Texas.
FAU - Bhat, Deepa
AU  - Bhat D
AD  - Office of Heath Systems Affairs., Dallas, Texas.
FAU - Fish, Jason
AU  - Fish J
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      Dallas, Texas.
FAU - Rubin, Craig D
AU  - Rubin CD
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      Dallas, Texas.
LA  - eng
GR  - T35 AG038048/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20170317
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
RN  - 0 (Anti-Infective Agents, Urinary)
RN  - 927AH8112L (Nitrofurantoin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Infective Agents, Urinary/*adverse effects/therapeutic use
MH  - *Chemical and Drug Induced Liver Injury
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Electronic Health Records/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Iatrogenic Disease
MH  - Lung Diseases/*chemically induced
MH  - Male
MH  - Nitrofurantoin/*adverse effects/therapeutic use
MH  - Retrospective Studies
PMC - PMC5478436
MID - NIHMS837413
OTO - NOTNLM
OT  - Beers criteria
OT  - adverse drug events
OT  - hepatotoxicity
OT  - nitrofurantoin
OT  - pulmonary toxicity
EDAT- 2017/03/18 06:00
MHDA- 2017/08/09 06:00
PMCR- 2018/06/01
CRDT- 2017/03/18 06:00
PHST- 2017/03/18 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2017/03/18 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 10.1111/jgs.14796 [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2017 Jun;65(6):1316-1320. doi: 10.1111/jgs.14796. Epub 2017 Mar 
      17.