PMID- 28306361
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180430
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 42
IP  - 7
DP  - 2017 Jul
TI  - Visual Field Progression is Associated with Systemic Concentration of Macrophage 
      Chemoattractant Protein-1 in Normal-Tension Glaucoma.
PG  - 1002-1006
LID - 10.1080/02713683.2016.1276193 [doi]
AB  - PURPOSE: To investigate the associations between endothelin-1 (ET-1) and 
      macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) 
      progression in normal-tension glaucoma (NTG). METHODS: We conducted a 
      prospective, longitudinal study in 71 patients with NTG. Blood samples from all 
      subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic 
      examinations, including the VF, were performed. Baseline data were compared with 
      follow-up data over 3 years. RESULTS: After 3 years of follow-up, 14 of the 71 
      patients showed VF progression, and the systemic MCP-1 level was significantly 
      associated with VF progression (r = 0.318, p = 0.007). Multiple regression 
      analysis showed that VF progression was significantly associated with MCP-1 (odds 
      ratio, OR = 1.021, 95% CI = 1.003-1.040; p = 0.020) and optic disc hemorrhage 
      (ODH; OR = 1.573; 95% CI = 1.140-2.170; p = 0.023). CONCLUSIONS: Systemic MCP-1 
      levels were associated with VF progression in patients with NTG.
FAU - Lee, Na Young
AU  - Lee NY
AD  - a College of Medicine , The Catholic University of Korea , Seoul , Korea.
AD  - b Department of Ophthalmology , Incheon St. Mary's Hospital , Incheon , Korea.
FAU - Kim, Min Hee
AU  - Kim MH
AD  - a College of Medicine , The Catholic University of Korea , Seoul , Korea.
AD  - c Department of Ophthalmology , Yeouido St. Mary's Hospital , Seoul , Korea.
FAU - Park, Chan Kee
AU  - Park CK
AD  - a College of Medicine , The Catholic University of Korea , Seoul , Korea.
AD  - d Department of Ophthalmology , Seoul St. Mary's Hospital , Seoul , Korea.
LA  - eng
PT  - Journal Article
DEP - 20170317
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Chemokine CCL2/*metabolism
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Low Tension Glaucoma/complications/metabolism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Scotoma/etiology/metabolism/*physiopathology
MH  - Time Factors
MH  - Visual Fields/*physiology
OTO - NOTNLM
OT  - Endothelin-1
OT  - macrophage chemoattractant protein-1
OT  - normal-tension glaucoma
OT  - progression
OT  - visual field
EDAT- 2017/03/18 06:00
MHDA- 2018/01/18 06:00
CRDT- 2017/03/18 06:00
PHST- 2017/03/18 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/03/18 06:00 [entrez]
AID - 10.1080/02713683.2016.1276193 [doi]
PST - ppublish
SO  - Curr Eye Res. 2017 Jul;42(7):1002-1006. doi: 10.1080/02713683.2016.1276193. Epub 
      2017 Mar 17.