PMID- 28306543
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20220331
IS  - 2191-0200 (Electronic)
IS  - 0334-1763 (Linking)
VI  - 28
IP  - 5
DP  - 2017 Jul 26
TI  - Peripheral levels of BDNF and opiate-use disorder: literature review and update.
PG  - 499-508
LID - 10.1515/revneuro-2016-0078 [doi]
AB  - Several neurobiological factors are related to opiate-use disorder (OUD), and 
      among them, neurotrophins have a relevant role. Brain-derived neurotrophic factor 
      (BDNF) is a central neurotrophin involved in many neuronal processes, and it has 
      been related to several psychiatric diseases and addictive disorders. BDNF can be 
      measured in plasma and serum; its levels may reflect BDNF concentrations in the 
      central nervous system (CNS) and, indirectly, CNS processes. Hence, peripheral 
      BDNF could be a biomarker in clinical practice. This manuscript explores the 
      findings about peripheral BDNF and OUD in humans. Opiates induce neurotoxicity in 
      the CNS, which may be correlated with modifications in BDNF expression. Thus, 
      basal levels of peripheral BDNF in OUD patients may be altered, which could be 
      modified with abstinence. Also, opiates may modify epigenetic processes that may 
      be associated with peripheral concentrations of BDNF, and in this line, 
      withdrawal could reflect recovering processes in the CNS. Additionally, treatment 
      modifies the peripheral concentrations of BDNF, but the clinical implications of 
      those changes are yet not elucidated. No specific conclusion can be performed and 
      more investigation in this area is necessary to elucidate the real potential of 
      peripheral BDNF as a biomarker.
FAU - Palma-Alvarez, Raul Felipe
AU  - Palma-Alvarez RF
AD  - .
FAU - Ros-Cucurull, Elena
AU  - Ros-Cucurull E
AD  - .
FAU - Amaro-Hosey, Kristopher
AU  - Amaro-Hosey K
AD  - .
FAU - Rodriguez-Cintas, Laia
AU  - Rodriguez-Cintas L
AD  - .
FAU - Grau-Lopez, Lara
AU  - Grau-Lopez L
AD  - .
FAU - Corominas-Roso, Margarida
AU  - Corominas-Roso M
AD  - .
FAU - Sanchez-Mora, Cristina
AU  - Sanchez-Mora C
AD  - .
FAU - Roncero, Carlos
AU  - Roncero C
AD  - .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*blood/metabolism
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Opioid-Related Disorders/blood/genetics/*metabolism/therapy
OTO - NOTNLM
OT  - BDNF
OT  - biomarker
OT  - heroin
OT  - opiate
OT  - opiate-use disorder
EDAT- 2017/03/18 06:00
MHDA- 2018/03/06 06:00
CRDT- 2017/03/18 06:00
PHST- 2016/11/28 00:00 [received]
PHST- 2017/01/25 00:00 [accepted]
PHST- 2017/03/18 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/03/18 06:00 [entrez]
AID - /j/revneuro.ahead-of-print/revneuro-2016-0078/revneuro-2016-0078.xml [pii]
AID - 10.1515/revneuro-2016-0078 [doi]
PST - ppublish
SO  - Rev Neurosci. 2017 Jul 26;28(5):499-508. doi: 10.1515/revneuro-2016-0078.