PMID- 2830866
OWN - NLM
STAT- MEDLINE
DCOM- 19880407
LR  - 20190903
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 61
IP  - 2
DP  - 1987 Dec
TI  - In vivo and in vitro interactions of TCDD and other ligands of the Ah-receptor: 
      effect on embryonic and fetal tissues.
PG  - 145-9
AB  - Interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and other ligands of 
      the Ah-receptor, had been studied in vivo, in pregnant NMRI mice, and in vitro, 
      in the fetal thymus organ culture system. Benzo(a)pyrene (BP) increased 
      TCDD-induced fetolethality, whereas it did not affect the rate of cleft palate 
      formation. This may indicate that the mechanism of TCDD-induced fetal death is 
      different from that of TCDD-induced cleft palate. 2,3,7,8-Tetrachlorodibenzofuran 
      (TCDBF) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) were added together to the 
      thymus organ culture, each at a concentration that caused about 25-50% lymphoid 
      development inhibition. Such treatment resulted in an additive effect of about 
      75%. Similarly, when the slightly toxic beta-naphthoflavone (BN) was added 
      together with TCDD to the same culture system, it caused a significant increase 
      in the lymphoid inhibitory effect of the latter compound. These may all suggest a 
      common mechanism of action for TCDD and other ligands, which may involve a direct 
      interaction with the receptors present in the thymus.
FAU - Hassoun, E A
AU  - Hassoun EA
AD  - University of Baghdad, Department of Toxicology, College of Pharmacy, Iraq.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Dioxins)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Receptors, Drug)
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology
MH  - Animals
MH  - Benzo(a)pyrene/pharmacology
MH  - Dioxins/*toxicity
MH  - Embryo, Mammalian
MH  - Female
MH  - Fetal Death/chemically induced
MH  - Fetus
MH  - Humans
MH  - Lymphocytes/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Organ Culture Techniques
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Pregnancy
MH  - Receptors, Aryl Hydrocarbon
MH  - Receptors, Drug/*drug effects
MH  - Thymus Gland/*drug effects
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 10.1007/BF00661373 [doi]
PST - ppublish
SO  - Arch Toxicol. 1987 Dec;61(2):145-9. doi: 10.1007/BF00661373.