PMID- 28314643
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20221207
IS  - 2241-5955 (Electronic)
IS  - 1109-9666 (Linking)
VI  - 57
IP  - 5
DP  - 2016 Sep-Oct
TI  - Acute ascending aortic dissection after MDMA/ecstasy use: A case report.
PG  - 351-354
LID - S1109-9666(16)30307-4 [pii]
LID - 10.1016/j.hjc.2016.11.026 [doi]
AB  - Acute aortic dissection is rare among young patients in the absence of connective 
      tissue disorders. One of the risk factors associated with aortic dissection among 
      young patients is amphetamine use. We report a case of a 37-year-old female with 
      a past medical history of hypertension presenting with syncope and altered mental 
      status who was found to have an acute DeBakey Type I aortic dissection after 
      ingestion of 3,4-methylenedioxymethamphetamine (MDMA), commonly known as ecstasy. 
      This is the second case in the literature describing aortic dissection in 
      relation to MDMA use. In both cases, the patients were young and had no history 
      of connective tissue disorders or underlying valvular abnormalities. In this 
      case, echocardiography was used to establish the diagnosis early. A transthoracic 
      echocardiogram revealed a possible dissection flap prolapsing in through a normal 
      aortic valve. Subsequently, a transesophageal echocardiogram revealed wide-open 
      aortic regurgitation with several proximal dissection flaps from a normal caliber 
      ascending aorta prolapsing into a normal tricuspid aortic valve. A high index of 
      suspicion is necessary to diagnose and treat aortic dissection in young patients 
      with a history of MDMA use. LEARNING OBJECTIVE: Recognize MDMA as a risk factor 
      for acute aortic dissection, especially among younger patients with whom 
      clinicians may not often associate aortic dissection.
CI  - Copyright (c) 2016 Hellenic Cardiological Society. Published by Elsevier B.V. All 
      rights reserved.
FAU - Kanahara, Satoko
AU  - Kanahara S
AD  - Department of Medicine and Section of Cardiology, Baylor College of Medicine, 
      Houston, Texas, USA.
FAU - El-Refai, Mostafa
AU  - El-Refai M
AD  - Department of Medicine and Section of Cardiology, Baylor College of Medicine, 
      Houston, Texas, USA. Electronic address: elrefai@bcm.edu.
FAU - Lakkis, Nasser
AU  - Lakkis N
AD  - Department of Medicine and Section of Cardiology, Baylor College of Medicine, 
      Houston, Texas, USA.
FAU - Tabbaa, Rashed
AU  - Tabbaa R
AD  - Department of Medicine and Section of Cardiology, Baylor College of Medicine, 
      Houston, Texas, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161115
PL  - Netherlands
TA  - Hellenic J Cardiol
JT  - Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
JID - 101257381
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Aortic Dissection/chemically induced/*diagnostic imaging
MH  - Aortic Aneurysm/chemically induced/*diagnostic imaging/surgery
MH  - Aortic Valve Insufficiency/*diagnostic imaging/surgery
MH  - Early Diagnosis
MH  - Echocardiography, Transesophageal
MH  - Female
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Syncope/chemically induced
OTO - NOTNLM
OT  - 3,4-Methylenedioxymethamphetamine
OT  - Acute aortic dissection
OT  - Aortic regurgitation
OT  - Ecstasy
OT  - MDMA
EDAT- 2017/03/21 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/03/19 06:00
PHST- 2014/08/19 00:00 [received]
PHST- 2015/06/26 00:00 [accepted]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/03/19 06:00 [entrez]
AID - S1109-9666(16)30307-4 [pii]
AID - 10.1016/j.hjc.2016.11.026 [doi]
PST - ppublish
SO  - Hellenic J Cardiol. 2016 Sep-Oct;57(5):351-354. doi: 10.1016/j.hjc.2016.11.026. 
      Epub 2016 Nov 15.