PMID- 28315311
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20181202
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1663
DP  - 2017 May 15
TI  - The effects of CRF and urocortins on the sociability of mice.
PG  - 114-122
LID - S0006-8993(17)30112-9 [pii]
LID - 10.1016/j.brainres.2017.03.003 [doi]
AB  - The aim of our study was to determine the role of corticotropin-releasing factor 
      (CRF), the urocortins (Ucn1, Ucn2 and Ucn3) and their receptors (CRF(1) and 
      CRF(2)) in the sociability of mice. Male CFLP mice were administered 
      intracerebroventricularly (icv) with CRF and urocortins alone or in combination 
      with antalarmin (specific CRF(1) antagonist) and astressin(2B) (specific CRF(2) 
      antagonist) and then investigated in a Crawley social interaction test arena, 
      that consists of three chambers. An unknown male in a cage was put in the first 
      chamber and an empty cage was put in the opposite chamber. The tested male was 
      habituated with the middle chamber for 5min and then allowed to explore the 
      remaining chambers for 5min, during which the number of entries and the time of 
      interaction were measured. Intracerebroventricular administration of CRF 
      decreased significantly the number of entries and the time of interaction with 
      the unknown male and these effects were blocked by antalarmin, but not 
      astressin(2B). In contrast, central administration of Ucn1 increased 
      significantly the number of entries into the chamber of the unknown male, without 
      changing the time of interaction and this effect was blocked by astressin(2B), 
      but not antalarmin. Central administration of Ucn2 and Ucn3 didn't influence 
      remarkably the number of entries, but it reduced the time of interaction between 
      the male mice. Our study suggests that CRF and Ucn1 may play important, but 
      different roles in sociability, and that Ucn2 and Ucn3, playing similar roles, 
      must be also involved in social interactions.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Bagosi, Zsolt
AU  - Bagosi Z
AD  - Department of Pathophysiology, Faculty of Medicine, University of Szeged, 
      Hungary. Electronic address: bagosi.zsolt@med.u-szeged.hu.
FAU - Karasz, Gergely
AU  - Karasz G
AD  - Department of Pathophysiology, Faculty of Medicine, University of Szeged, 
      Hungary.
FAU - Czebely-Lenart, Andras
AU  - Czebely-Lenart A
AD  - Department of Pathophysiology, Faculty of Medicine, University of Szeged, 
      Hungary.
FAU - Csabafi, Krisztina
AU  - Csabafi K
AD  - Department of Pathophysiology, Faculty of Medicine, University of Szeged, 
      Hungary.
FAU - Jaszberenyi, Miklos
AU  - Jaszberenyi M
AD  - Department of Pathophysiology, Faculty of Medicine, University of Szeged, 
      Hungary.
FAU - Telegdy, Gyula
AU  - Telegdy G
AD  - Department of Pathophysiology, Faculty of Medicine, University of Szeged, 
      Hungary.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (CRF receptor type 2)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Pyrimidines)
RN  - 0 (Pyrroles)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Urocortins)
RN  - 0 (antalarmin)
RN  - 0 (astressin-2B)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Corticotropin-Releasing Hormone/drug effects/*metabolism/*pharmacology
MH  - Male
MH  - Mice
MH  - Peptide Fragments
MH  - Peptides, Cyclic
MH  - Pyrimidines
MH  - Pyrroles
MH  - Receptors, Corticotropin-Releasing Hormone/metabolism
MH  - Social Behavior
MH  - Urocortins/*metabolism/pharmacology
OTO - NOTNLM
OT  - CRF
OT  - Mice
OT  - Sociability
OT  - Urocortins
EDAT- 2017/03/21 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/03/19 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/03/02 00:00 [revised]
PHST- 2017/03/03 00:00 [accepted]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/03/19 06:00 [entrez]
AID - S0006-8993(17)30112-9 [pii]
AID - 10.1016/j.brainres.2017.03.003 [doi]
PST - ppublish
SO  - Brain Res. 2017 May 15;1663:114-122. doi: 10.1016/j.brainres.2017.03.003. Epub 
      2017 Mar 14.