PMID- 28316567
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240324
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 11
DP  - 2017
TI  - Distinct Functional Connectivities Predict Clinical Response with Emotion 
      Regulation Therapy.
PG  - 86
LID - 10.3389/fnhum.2017.00086 [doi]
LID - 86
AB  - Despite the success of available medical and psychosocial treatments, a sizable 
      subgroup of individuals with commonly co-occurring disorders, generalized anxiety 
      disorder (GAD) and major depressive disorder (MDD), fail to make sufficient 
      treatment gains thereby prolonging their deficits in life functioning and 
      satisfaction. Clinically, these patients often display temperamental features 
      reflecting heightened sensitivity to underlying motivational systems related to 
      threat/safety and reward/loss (e.g., somatic anxiety) as well as inordinate 
      negative self-referential processing (e.g., worry, rumination). This profile may 
      reflect disruption in two important neural networks associated with 
      emotional/motivational salience (e.g., salience network) and self-referentiality 
      (e.g., default network, DN). Emotion Regulation Therapy (ERT) was developed to 
      target this hypothesized profile and its neurobehavioral markers. In the present 
      study, 22 GAD patients (with and without MDD) completed resting state MRI scans 
      before receiving 16 sessions of ERT. To test study these hypotheses, we examined 
      the associations between baseline patterns of intrinsic functional connectivity 
      (iFC) of the insula and of hubs within the DN (anterior and dorsal medial 
      prefrontal cortex [MPFC] and posterior cingulate cortex [PCC]) and 
      treatment-related changes in worry, somatic anxiety symptoms and decentering. 
      Results suggest that greater treatment linked reductions in worry were associated 
      with iFC clusters in both the insular and parietal cortices. Greater treatment 
      linked gains in decentering, a metacognitive process that involves the capacity 
      to observe items that arise in the mind with healthy psychological distance that 
      is targeted by ERT, was associated with iFC clusters in the anterior and 
      posterior DN. The current study adds to the growing body of research implicating 
      disruptions in the default and salience networks as promising targets of 
      treatment for GAD with and without co-occurring MDD.
FAU - Fresco, David M
AU  - Fresco DM
AD  - Department of Psychological Sciences, Kent State UniversityKent, OH, USA; 
      Department of Psychiatry, Case Western Reserve University School of 
      MedicineCleveland, OH, USA.
FAU - Roy, Amy K
AU  - Roy AK
AD  - Department of Psychology, Fordham University Bronx, NY, USA.
FAU - Adelsberg, Samantha
AU  - Adelsberg S
AD  - Department of Psychology, Fordham University Bronx, NY, USA.
FAU - Seeley, Saren
AU  - Seeley S
AD  - Department of Psychology, University of Arizona Tucson, AZ, USA.
FAU - Garcia-Lesy, Emmanuel
AU  - Garcia-Lesy E
AD  - The Graduate Center, City University of New YorkNew York, NY, USA; Hunter 
      College, City University of New YorkNew York, NY, USA.
FAU - Liston, Conor
AU  - Liston C
AD  - Department of Psychiatry, Weill Cornell Medical College New York, NY, USA.
FAU - Mennin, Douglas S
AU  - Mennin DS
AD  - The Graduate Center, City University of New YorkNew York, NY, USA; Hunter 
      College, City University of New YorkNew York, NY, USA.
LA  - eng
GR  - P30 NR015326/NR/NINR NIH HHS/United States
GR  - R01 HL119977/HL/NHLBI NIH HHS/United States
GR  - R25 GM060665/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170303
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC5334508
OTO - NOTNLM
OT  - decentering
OT  - generalized anxiety disorder
OT  - major depressive disorder
OT  - resting state functional connectivity
OT  - somatic anxiety
OT  - worry
EDAT- 2017/03/21 06:00
MHDA- 2017/03/21 06:01
PMCR- 2017/01/01
CRDT- 2017/03/21 06:00
PHST- 2016/09/14 00:00 [received]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/03/21 06:00 [entrez]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2017/03/21 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2017.00086 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2017 Mar 3;11:86. doi: 10.3389/fnhum.2017.00086. eCollection 
      2017.