PMID- 28317287
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20220129
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 29
IP  - 8
DP  - 2017 Aug
TI  - The BDNF polymorphism Val66Met may be predictive of swallowing improvement post 
      pharyngeal electrical stimulation in dysphagic stroke patients.
LID - 10.1111/nmo.13062 [doi]
AB  - BACKGROUND: The aim of this study was to explore the effect of brain-derived 
      neurotrophic factor (BDNF) polymorphism rs6265 (Val66Met) in both "natural" and 
      treatment induced recovery of swallowing after dysphagic stroke. METHODS: Sixteen 
      dysphagic stroke patients that completed a single-blind randomized sham 
      controlled trial of pharyngeal electrical stimulation (PES) within 6 weeks of 
      their stroke (N=38), were genotyped for the BDNF SNP Val66Met (rs6265) from 
      saliva samples. These patients received active or sham PES according to 
      randomized allocation. PES was delivered at a set frequency (5 Hz), intensity 
      (75% of maximal tolerated), and duration (10 minutes) once a day for three 
      consecutive days. Clinical measurements were taken from patients at baseline, 
      2 weeks and 3 months post entering the study. Changes in swallowing ability based 
      on the dysphagia severity rating scale (DSRS) were compared between active and 
      sham groups and associated with BDNF SNP status. KEY RESULTS: In the active 
      stimulation group, patients with the Met BDNF allele demonstrated significantly 
      greater improvements in DSRS at 3 months compared to patients homozygous for the 
      Val allele (P=.009). By comparison, there were no significant associations at the 
      2 week stage in either the active or sham group, or at 3 month in the sham group. 
      Functional scores including the Barthel Index and modified Rankin scale were also 
      unaffected by BDNF status. CONCLUSIONS & INFERENCES: Our findings suggest an 
      association between BDNF and stimulation induced swallowing recovery. Further 
      work will be required to validate these observations and demonstrate clinical 
      utility in patients.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Essa, H
AU  - Essa H
AUID- ORCID: 0000-0001-9445-2582
AD  - University of Manchester, Division of Diabetes, Endocrinology and 
      Gastroenterology, Gastrointestinal Sciences, Faculty of Biology, Medicine and 
      Health, The University of Manchester, Manchester, UK.
FAU - Vasant, D H
AU  - Vasant DH
AD  - University of Manchester, Division of Diabetes, Endocrinology and 
      Gastroenterology, Gastrointestinal Sciences, Faculty of Biology, Medicine and 
      Health, The University of Manchester, Manchester, UK.
FAU - Raginis-Zborowska, A
AU  - Raginis-Zborowska A
AD  - University of Manchester, Division of Diabetes, Endocrinology and 
      Gastroenterology, Gastrointestinal Sciences, Faculty of Biology, Medicine and 
      Health, The University of Manchester, Manchester, UK.
FAU - Payton, A
AU  - Payton A
AD  - University of Manchester, Division of Diabetes, Endocrinology and 
      Gastroenterology, Gastrointestinal Sciences, Faculty of Biology, Medicine and 
      Health, The University of Manchester, Manchester, UK.
AD  - School of Health Sciences, Division of Human Communication, Development & 
      Hearing, The University of Manchester, Manchester, UK.
FAU - Michou, E
AU  - Michou E
AD  - University of Manchester, Division of Diabetes, Endocrinology and 
      Gastroenterology, Gastrointestinal Sciences, Faculty of Biology, Medicine and 
      Health, The University of Manchester, Manchester, UK.
FAU - Hamdy, S
AU  - Hamdy S
AD  - University of Manchester, Division of Diabetes, Endocrinology and 
      Gastroenterology, Gastrointestinal Sciences, Faculty of Biology, Medicine and 
      Health, The University of Manchester, Manchester, UK.
LA  - eng
GR  - PB-PG-0107-12076/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170320
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Deglutition
MH  - Deglutition Disorders/*genetics/*therapy
MH  - Electric Stimulation Therapy
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pharynx/physiopathology
MH  - Polymorphism, Single Nucleotide
MH  - Severity of Illness Index
MH  - Single-Blind Method
MH  - Stroke/*complications/genetics
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BDNF
OT  - Dysphagia
OT  - PES
OT  - brain-derived neurotrophic factor
OT  - pharyngeal electrical stimulation
OT  - swallowing
EDAT- 2017/03/21 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/03/21 06:00
PHST- 2016/12/18 00:00 [received]
PHST- 2017/02/14 00:00 [accepted]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/03/21 06:00 [entrez]
AID - 10.1111/nmo.13062 [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2017 Aug;29(8). doi: 10.1111/nmo.13062. Epub 2017 Mar 
      20.