PMID- 28318471
OWN - NLM
STAT- MEDLINE
DCOM- 20180815
LR  - 20180816
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 29
IP  - 6
DP  - 2017 Dec
TI  - Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, 
      C-reactive protein and brain-derived neurotrophic factor.
PG  - 337-346
LID - 10.1017/neu.2017.2 [doi]
AB  - OBJECTIVE: This study aimed to explore effects of adjunctive N-acetylcysteine 
      (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. 
      METHODS: We embarked on a 12-week clinical trial of NAC (2000 mg/day compared 
      with placebo) as an adjunctive treatment for unipolar depression. A follow-up 
      visit was conducted 4 weeks following the completion of treatment. We collected 
      serum samples at baseline and the end of the treatment phase (week 12) to 
      determine changes in interleukin-6 (IL6), C-reactive protein (CRP) and 
      brain-derived neurotrophic factor (BDNF) following NAC treatment. RESULTS: NAC 
      treatment significantly improved depressive symptoms on the Montgomery-Asberg 
      Depression Rating Scale (MADRS) over 16 weeks of the trial. Serum levels of IL6 
      were associated with reductions of MADRS scores independent of treatment 
      response. However, we found no significant changes in IL6, CRP and BDNF levels 
      following NAC treatment. CONCLUSION: Overall, this suggests that our results 
      failed to support the hypothesis that IL6, CRP and BDNF are directly involved in 
      the therapeutic mechanism of NAC in depression. IL6 may be a useful marker for 
      future exploration of treatment response.
FAU - Hasebe, Kyoko
AU  - Hasebe K
AD  - 1School of Medicine,Centre for Molecular and Medical Research,Deakin 
      University,Geelong,Australia.
FAU - Gray, Laura
AU  - Gray L
AD  - 1School of Medicine,Centre for Molecular and Medical Research,Deakin 
      University,Geelong,Australia.
FAU - Bortolasci, Chiara
AU  - Bortolasci C
AD  - 1School of Medicine,Centre for Molecular and Medical Research,Deakin 
      University,Geelong,Australia.
FAU - Panizzutti, Bruna
AU  - Panizzutti B
AD  - 4Laboratory of Molecular Psychiatry,Hospital de clinicas de Porto 
      Alegre,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
FAU - Mohebbi, Mohammadreza
AU  - Mohebbi M
AD  - 5School of Medicine,IMPACT Strategic Research Centre,Deakin 
      University,Geelong,Australia.
FAU - Kidnapillai, Srisaiyini
AU  - Kidnapillai S
AD  - 1School of Medicine,Centre for Molecular and Medical Research,Deakin 
      University,Geelong,Australia.
FAU - Spolding, Briana
AU  - Spolding B
AD  - 1School of Medicine,Centre for Molecular and Medical Research,Deakin 
      University,Geelong,Australia.
FAU - Walder, Ken
AU  - Walder K
AD  - 1School of Medicine,Centre for Molecular and Medical Research,Deakin 
      University,Geelong,Australia.
FAU - Berk, Michael
AU  - Berk M
AD  - 2The Florey Institute of Neuroscience and Mental Health,Parkville,Australia.
FAU - Malhi, Gin
AU  - Malhi G
AD  - 8Discipline of Psychiatry,Sydney Medical School,University of 
      Sydney,Sydney,Australia.
FAU - Dodd, Seetal
AU  - Dodd S
AD  - 5School of Medicine,IMPACT Strategic Research Centre,Deakin 
      University,Geelong,Australia.
FAU - Dean, Olivia M
AU  - Dean OM
AD  - 2The Florey Institute of Neuroscience and Mental Health,Parkville,Australia.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170320
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - C-Reactive Protein/*analysis
MH  - Depressive Disorder/blood/*drug therapy
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - N-acetylcysteine
OT  - clinical trial
OT  - depression
OT  - inflammation
OT  - neurotrophic factor
EDAT- 2017/03/21 06:00
MHDA- 2018/08/16 06:00
CRDT- 2017/03/21 06:00
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2018/08/16 06:00 [medline]
PHST- 2017/03/21 06:00 [entrez]
AID - S0924270817000023 [pii]
AID - 10.1017/neu.2017.2 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2017 Dec;29(6):337-346. doi: 10.1017/neu.2017.2. Epub 2017 
      Mar 20.